Transcriptome Sequencing Investigated the Tumor-Related Factors Changes After T. gondii Infection

Frontiers in Microbiology
Gang LuLin Wang

Abstract

Toxoplasma gondii is an intracellular parasite and causes a global epidemic parasitic disease. T. gondii-infection could inhibit the growth of tumor. In this study, the transcriptomes of samples were detected by deep sequencing analysis. The transcriptome data was compared with reference genome to perform sequence alignment and the further analysis. The analyses of differential expression and the differentially expressed genes were performed in the present study. Genes involved in P53 signaling pathway, COLORECTAL cancer pathway, NON-SMALL CELL LUNG cancer signaling pathway, and BREAST cancer signaling pathway were up-regulated or down-regulated among the samples. The KEGG analysis indicated that the cancer pathways changed after infection of T. gondii. Furthermore, tumor-related mRNAs from different samples had a large difference, which suggested that the difference might provide important information in resisting cancer. The protein results indicated that tumor-related protein changes occurred after infection of T. gondii. In conclusion, the infection changed the cancer pathways, which could possibly inhibit the growth of tumor.

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Citations

Nov 17, 2020·Frontiers in Cell and Developmental Biology·Bruna Cristina BorgesMarcelo José Barbosa Silva

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Methods Mentioned

BETA
electrophoresis
PCR
RNA-seq

Software Mentioned

BREAST
SPSS
BEDtools

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