Transcriptomic Analysis Identifies the Effect of Beta-Blocking Agents on a Molecular Pathway of Contraction in the Heart and Predicts Response to Therapy

JACC. Basic to Translational Science
Bettina HeideckerJoshua M Hare

Abstract

Over the last decades, beta-blockers have been a key component of heart failure therapy. However, currently there is no method to identify patients who will benefit from beta-blocking therapy versus those who will be unresponsive or worsen. Furthermore, there is an unmet need to better understand molecular mechanisms through which heart failure therapies, such as beta-blockers, improve cardiac function, in order to design novel targeted therapies. Solving these issues is an important step towards personalized medicine. Here, we present a comprehensive transcriptomic analysis of molecular pathways that are affected by beta-blocking agents and a transcriptomic biomarker to predict therapy response.

References

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Mar 9, 2011·Circulation·Bettina HeideckerJoshua M Hare
Aug 1, 2012·Physiological Research·E KrejčíD Sedmera

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Citations

Aug 30, 2019·Journal of Women's Health·Dimitri PatrikiBettina Heidecker
Jul 16, 2020·International Journal of Molecular Sciences·Amela Jusic On Behalf Of The Eu-CardioRNA Cost Action

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Methods Mentioned

BETA
biopsies
biopsy
chips
nucleotide
GTPase
Nucleotide Exchange

Software Mentioned

MetaCore
SAM
GeneGo
R
MASS
MiPP
GeneGo Metacore
Meta Core

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