Transcriptomic analysis on the effects of melatonin in gastrointestinal carcinomas

BMC Gastroenterology
Lu AoRuixiang Zhou

Abstract

Melatonin has been shown with anticancer property and therapeutic potential for tumors. However, there lacks a systematic study on the molecular pathways of melatonin and its antitumor effects in gastrointestinal carcinomas. Using the gene expression profiles of four cancer cell lines from three types of gastrointestinal carcinomas before and after melatonin treatment, including gastric carcinoma (GC), colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC), differentially expressed genes (DEGs) and biological pathways influenced by melatonin were identified. The qRT-PCR analyses were performed to validate the effects of melatonin on 5-FU resistance-related genes in CRC. There were 17 pathways commonly altered by melatonin in the three cancer types, including FoxO signaling pathways enriched by the upregulated DEGs and cell cycle signaling pathways enriched by the downregulated DEGs, confirmed the dual role of melatonin to tumor growth, pro-apoptosis and anti-proliferation. DEGs upregulated in the three types of cancer tissues but reversely downregulated by melatonin were commonly enriched in RNA transport, spliceosome and cell cycle signaling pathways, which indicate that melatonin might exert antitumor effects through t...Continue Reading

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Citations

Jan 16, 2021·Antioxidants·Paula Fernández-PalancaJavier González-Gallego
May 12, 2021·Life Sciences·Russel J ReiterLuiz Gustavo de Almeida Chuffa

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Datasets Mentioned

BETA
GSE132119
GSE27342
GSE8671
GSE23878
GSE14520
GSE39791

Methods Mentioned

BETA
Assay

Software Mentioned

SIGnaling Network Open Resource ( SIGNOR )
SPSS

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