Transcriptomics and proteomics: advancing the understanding of genetic basis of fracture healing

Injury
Eleftherios Tsiridis, Peter V Giannoudis

Abstract

Fracture healing is a complex physiological post-natal process, which involves the coordination of several different cell types. Exploring the orchestration of events and the simultaneous activation of osteogenesis and chondrogenesis that recapitulates mammalian embryological skeletal development seems to be not only sophisticated but also challenging. A large number of genes involved in the above process are known, but many more remain to be discovered. The functional characterisation of these genes promises to elucidate the repair process as well as skeletal abnormalities and aging. We here review the current knowledge on early and late gene expression during fracture healing, the genes so far associated with osteoblast and osteoclast differentiation, the BMP antagonists, and the Wnts signalling pathway.

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Citations

Aug 30, 2008·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Safdar N KhanAaron Daluiski
Jan 29, 2008·Injury·Peter V GiannoudisDavid Marsh
Sep 23, 2008·Injury·Nikolaos K KanakarisPeter V Giannoudis
May 13, 2014·Surgical Neurology International·David StrausVincent C Traynelis
Apr 22, 2008·Expert Opinion on Pharmacotherapy·Tobias LindnerEleftherios Tsiridis
Sep 25, 2007·Injury·Peter V Giannoudis
Jun 21, 2007·Journal of Cellular Physiology·Lee A KabackHicham Drissi
Jan 17, 2012·Proteomics·Giulia BernardiniAnnalisa Santucci
Aug 4, 2016·JBJS Reviews·Mark R Brinker, Daniel P O'Connor
Feb 4, 2011·Acta Orthopaedica. Supplementum·Sigbjørn Dimmen

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