PMID: 9549742Apr 29, 1998Paper

Transcutaneous CO2 tension effects of clonidine in paediatric caudal analgesia

Paediatric Anaesthesia
A DupeyratC Ecoffey

Abstract

In adults, clonidine when added to bupivacaine, results in no detectable respiratory depressant effect except when carbon dioxide challenge is performed. However, to date no investigations have quantified this in children. Twenty-four children (nine months to seven years) were randomized in a double-blind study into two groups. After induction, a caudal block was performed with 1 ml.kg-1 0.25% bupivacaine. Clonidine 1 microgram.kg-1 was added in the clonidine group, and 1 ml normal saline in the placebo group. Patients were monitored in the recovery room for three h from arrival to discharge with continuous pulse oximetry, respiratory rate, a transcutaneous CO2 tension (tcPCO2) every 15 min, and a four point sedation score every 30 min. Mean tcPCO2 and respiratory rate values were not different between the two groups. Apnoea and desaturation less than 97% were not observed. The sedation score decreased with time in both groups, and the score time interval was significantly higher in the clonidine group (P < 0.05). All the patients left the recovery room with a sedation score of 1, excepting four in the clonidine group with a sedation score of 2. Clonidine 1 microgram.kg-1 with 0.25% bupivacaine mixture in caudal analgesia in ch...Continue Reading

References

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Citations

Sep 29, 1999·Pharmacology & Therapeutics·A R Lloyd-Thomas
May 3, 2000·Anaesthesia·S P Courtman, A S Carr
May 13, 1999·Paediatric Anaesthesia·K NishinaH Obara
Mar 14, 2012·Saudi Journal of Anaesthesia·Senthil Gopalakrishnan, Joseph D Tobias
Jul 31, 2004·Paediatric Anaesthesia·Paolo SilvaniIda Salvo
Sep 3, 2003·Paediatric Anaesthesia·Mark AnserminoCarolyne Montgomery
Jan 31, 2008·Paediatric Anaesthesia·Anja Pohl-SchickingerBrigitte Stiller
Aug 25, 2005·Clinical Therapeutics·Charles B BerdeDick Tibboel
Dec 21, 2002·Best Practice & Research. Clinical Anaesthesiology·John B Eck, Allison Kinder Ross
Sep 30, 2003·Southern Medical Journal·Joseph D TobiasPierantonio Russo
May 18, 2007·Acta Physiologica·Z BakB Janerot-Sjoberg
Oct 4, 2006·Current Opinion in Anaesthesiology·S A SchugH M Cardwell

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