PMID: 9651141Jul 3, 1998Paper

Transcutaneous electrical nerve stimulation (TENS) improves circadian rhythm disturbances in Alzheimer disease

Alzheimer Disease and Associated Disorders
E J Van SomerenD F Swaab

Abstract

In patients with Alzheimer disease (AD), an irregular day-night rhythm with behavioral restlessness during the night makes a strong demand on caregivers and is among the most important reasons for institutionalization. A dysfunctioning circadian timing system is supposed to underlie the disturbance or at least to contribute to it. The disturbance improves with increased environmental light, which, through the retinohypothalamic tract, activates the suprachiasmatic nucleus (SCN), the biological clock of the brain. Because recent studies have indicated both direct and indirect spinal projections to the SCN, we investigated whether excitation of spinal neurons by means of transcutaneous electrical nerve stimulation (TENS) could also improve circadian rhythm disturbances in AD patients. The actigraphically obtained rest-activity rhythm of 14 AD patients showed an improvement in its coupling to Zeitgeber after TENS treatment but not after placebo treatment.

Citations

Dec 15, 2005·Neuropsychological Rehabilitation·E B CooperJ B Cooper
Apr 2, 2005·Dementia and Geriatric Cognitive Disorders·Koene R A van DijkErik J A Scherder
Jan 21, 2006·Journal of Circadian Rhythms·Tuuli A LahtiTimo Partonen
May 2, 2013·Sleep·Bart H W te Lindert, Eus J W Van Someren
Jul 26, 2012·Journal of Neural Transmission·Els I S MostEus J W Van Someren
Apr 26, 2012·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Els I S MostEus J W Van Someren
Sep 14, 2010·Experimental Gerontology·Dick F Swaab, Ai-Min Bao
Jan 9, 2010·Sleep Medicine Reviews·Patricia L TurnerMartin A Mainster
Nov 21, 2007·Sleep Medicine Reviews·Eus J W Van Someren, Rixt F Riemersma-Van Der Lek
Mar 21, 2007·Sleep Medicine·Eus J W Van Someren
Feb 24, 2005·Journal of Pineal Research·Ying-Hui Wu, Dick F Swaab
Nov 23, 2006·Journal of Sleep Research·Koene R A Van DijkErik J A Scherder
Sep 28, 2010·International Journal of Geriatric Psychiatry·Oludamilola SalamiVani Rao
Sep 25, 2003·Neurological Research·Dick F Swaab
Aug 7, 2013·Journal of Receptor and Signal Transduction Research·Peter Kovacic, Ratnasamy Somanathan
Jul 30, 2014·Sleep Medicine Reviews·B S B GonçalvesJohn Fontenele Araujo
Aug 15, 2003·The Cochrane Database of Systematic Reviews·M CameronH Lee
Sep 27, 2003·Alzheimer Disease and Associated Disorders·D F SwaabR W H Verwer
Mar 3, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Benoît MauvieuxDamien Davenne

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