Transcutaneous induction of stimulus-timing-dependent plasticity in dorsal cochlear nucleus

Frontiers in Systems Neuroscience
Calvin WuSusan E Shore

Abstract

The cochlear nucleus (CN) is the first site of multisensory integration in the ascending auditory pathway. The principal output neurons of the dorsal cochlear nucleus (DCN), fusiform cells, receive somatosensory information relayed by the CN granule cells from the trigeminal and dorsal column pathways. Integration of somatosensory and auditory inputs results in long-term enhancement or suppression in a stimulus-timing-dependent manner. Here, we demonstrate that stimulus-timing-dependent plasticity (STDP) can be induced in DCN fusiform cells using paired auditory and transcutaneous electrical stimulation of the face and neck to activate trigeminal and dorsal column pathways to the CN, respectively. Long-lasting changes in fusiform cell firing rates persisted for up to 2 h after this bimodal stimulation, and followed Hebbian or anti-Hebbian rules, depending on tone duration, but not somatosensory stimulation location: 50 ms paired tones evoked predominantly Hebbian, while 10 ms paired tones evoked predominantly anti-Hebbian plasticity. The tone-duration-dependent STDP was strongly correlated with first inter-spike intervals, implicating intrinsic cellular properties as determinants of STDP. This study demonstrates that transcutan...Continue Reading

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Citations

Jun 17, 2016·Neuromodulation : Journal of the International Neuromodulation Society·Caroline HamiltonBrendan J Conlon
Jul 21, 2016·Hearing Research·Donald A GodfreyRickye S Heffner
Dec 14, 2018·Expert Opinion on Emerging Drugs·Christopher R CederrothBerthold Langguth

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