Transcutaneous yellow fever vaccination of subjects with or without atopic dermatitis

The Journal of Allergy and Clinical Immunology
Mark K SlifkaJon Hanifin

Abstract

Atopic dermatitis (AD) is a common inflammatory skin disease with a global prevalence ranging from 3% to 20%. Patients with AD have an increased risk for complications after viral infection (eg, herpes simplex virus), and vaccination of patients with AD with live vaccinia virus is contraindicated because of a heightened risk of eczema vaccinatum, a rare but potentially lethal complication associated with smallpox vaccination. We sought to develop a better understanding of immunity to cutaneous viral infection in patients with AD. In a double-blind randomized study we investigated the safety and immunogenicity of live attenuated yellow fever virus (YFV) vaccination of nonatopic subjects and patients with AD after standard subcutaneous inoculation or transcutaneous vaccination administered with a bifurcated needle. Viremia, neutralizing antibody, and antiviral T-cell responses were analyzed for up to 30 days after vaccination. YFV vaccination administered through either route was well tolerated. Subcutaneous vaccination resulted in higher seroconversion rates than transcutaneous vaccination but elicited similar antiviral antibody levels and T-cell responses in both the nonatopic and AD groups. After transcutaneous vaccination, bo...Continue Reading

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Citations

Jan 16, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Monika KauravRavi Shankar Pandey
Jan 8, 2016·The Journal of Allergy and Clinical Immunology·Hyo Jin KwonYoung J Juhn
Feb 5, 2015·The Journal of Allergy and Clinical Immunology·Michiko K OyoshiRaif S Geha
Apr 7, 2015·The Journal of Allergy and Clinical Immunology·Michelle A Barron, Donald Y M Leung
Feb 11, 2015·The Journal of Allergy and Clinical Immunology·Scott H Sicherer, Donald Y M Leung
Jan 15, 2015·The Journal of Allergy and Clinical Immunology·Joel Correa da RosaEmma Guttman-Yassky
Jan 15, 2017·The Journal of Allergy and Clinical Immunology·Regina K RoweMichelle A Gill
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Apr 25, 2017·Clinical & Translational Immunology·Laura Lazo VázquezLisset Hermida Cruz
Feb 25, 2017·Current Allergy and Asthma Reports·Regina K Rowe, Michelle A Gill

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