Transdermal absorption of (-)-linalool induces autonomic deactivation but has no impact on ratings of well-being in humans

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Eva HeubergerGerhard Buchbauer

Abstract

Essential lavender oil has a long tradition as a mild sedative in herbal medicine. Relaxing effects after inhalation have also been demonstrated for one of its main constituents, (-)-linalool. The aim of the present investigation was to determine the effects of this monoterpenoid alcohol on human physiological parameters (blood oxygen saturation, breathing rate, eye-blink rate, pulse rate, skin conductance, skin temperature, surface electromyogram as well as systolic and diastolic blood pressure) and assessments of subjective well-being. (-)-Linalool was applied to 14 healthy subjects by percutaneous administration. Inhalation of the fragrance was prevented by means of breathing masks. (-)-Linalool induced deactivation with respect to physiology, that is, a decrease of systolic blood pressure and a smaller decrease of skin temperature, compared to a corresponding control group receiving a placebo, but had no effects on subjective evaluation of well-being.

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Citations

Dec 24, 2008·Holistic Nursing Practice·Sallie Stoltz Denner
Dec 14, 2011·Sensors·Andrew J Johnson
Oct 21, 2014·Journal of Research in Pharmacy Practice·Md ZabirunnisaChandrasekhar Thatimatla
Feb 3, 2016·BMC Neurology·Geun-Hye SeolGeun Hee Seol
Oct 11, 2011·Complementary Therapies in Clinical Practice·Catriona Jones
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Jul 19, 2008·Archives of Oral Biology·Masahiro Toda, Kanehisa Morimoto
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May 2, 2015·World Journal of Microbiology & Biotechnology·Ruchira Mukherji, Asmita Prabhune
Jan 28, 2015·The Journal of Pharmacy and Pharmacology·Purum Kang, Geun Hee Seol
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Apr 13, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Ai TakedaSachiyo Koyama
Oct 21, 2020·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Helene M LoosBrid Karacan

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