PMID: 11337153May 5, 2001Paper

Transdermal administration of salmon calcitonin by pulse depolarization-iontophoresis in rats

International Journal of Pharmaceutics
K NakamuraK Yamamoto

Abstract

Using the pulse depolarization-iontophoresis (PDP-IP) system, salmon calcitonin (sCT), a drug for the treatment of osteoporosis, was transdermaly administered in rats. While absorption of sCT was not observed after passive transdermal administration, the serum sCT concentration was confirmed at a dose of 0.2-4 microg when the PDP-IP system was employed. The results indicated that PDP-IP could enhance transdermal absorption of peptide drugs. Also noted was the increased amount of absorption of sCT along with an increase in the dose. We investigated the influence of electrical parameters (current, frequency) in PDP-IP on the transdermal absorption of sCT. An optimal current for drug absorption was found within the range of transported current (0.1-1.0 mA) employed for PDP-IP. In comparison with the results obtained at 0.1 mA, the drug absorption increased, along with an increase in transported current, when the current was set at 0.5 mA, while the drug absorption decreased at 1.0 mA in comparison. The decrease in drug absorption was assumed to be attributable to the structural destruction of skin by application of excessive current. There was no change in skin resistance attributable to the frequency; nor was there any influence ...Continue Reading

References

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Citations

Mar 17, 2004·Advanced Drug Delivery Reviews·Yogeshvar N KaliaRichard H Guy
May 17, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Seiji TokumotoKenji Sugibayashi
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Kevin LiMatthew S Hastings
Dec 7, 2010·Therapeutic Delivery·Kalpana S PaudelAudra L Stinchcomb
Sep 26, 2015·Journal of Drug Targeting·Kevin Ita
Apr 16, 2013·Dental Materials : Official Publication of the Academy of Dental Materials·Mangala P PatelDavid M Williams
May 31, 2012·Journal of Pharmaceutical Sciences·Viswatej VemulapalliAjay K Banga
May 9, 2012·Drug Development and Industrial Pharmacy·Jiradej ManosroiAranya Manosroi
Mar 25, 2011·Expert Opinion on Drug Delivery·Taís GratieriYogeshvar N Kalia
Nov 5, 2011·Physical Therapy·Izabella GomezZoltán Szekanecz
Aug 18, 2017·Pharmaceutical Development and Technology·S ArunkumarS Narasimha Murthy
Sep 20, 2005·Pharmaceutical Research·Nada AblaYogeshvar N Kalia
Sep 10, 2015·Drug Delivery and Translational Research·Ali Aghazadeh-HabashiMichael R Doschak

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