Transdermal applications of ethosomes - a detailed review

Journal of Liposome Research
Nidhi NainwalVikas Anand Saharan

Abstract

Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum (SC) acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular carrier containing high ethanol concentrations and offer improved skin permeability and efficient bioavailability due to their structure and composition. This article gives a review of ethosomes including their compositions, types, mechanism of drug delivery, stability, and safety behaviour. This article also provides a detailed overview of drug delivery applications of ethosomes in various diseases.

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Citations

Dec 5, 2020·Pharmaceutical Development and Technology·Rajesh Sreedharan NairAndrew P Morris
Mar 18, 2021·Drug Delivery and Translational Research·Tai WangXiaoliang Zhu
May 20, 2021·Journal of Veterinary Pharmacology and Therapeutics·Kaixiang ZhouLingli Huang
Jul 22, 2021·Drug Delivery and Translational Research·Zhiyue ZhaoNan Li
Sep 29, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Valeria NeleMolly M Stevens

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