Transdermal Bioavailability in Rats of Lidocaine in the Forms of Ionic Liquids, Salts, and Deep Eutectic

ACS Medicinal Chemistry Letters
Paula BertonRobin D Rogers

Abstract

Tuning the bioavailability of lidocaine was explored by its incorporation into the ionic liquid lidocainium docusate ([Lid][Doc]) and the deep eutectic Lidocaine·Ibuprofen (Lid·Ibu) and comparing the transdermal absorption of these with the crystalline salt lidocainium chloride ([Lid]Cl). Each form of lidocaine was dissolved in a vehicle cream and topically applied to Sprague-Dawley rats. The concentrations of the active pharmaceutical ingredients (APIs) in blood plasma were monitored over time as an indication of systemic absorption. The concentration of lidocaine in plasma varied between applied API-based creams, with faster and higher systemic absorption of the hydrogen bonded deep eutectic Lid·Ibu than the absorption of the salts [Lid]Cl or [Lid][Doc]. Interestingly, a differential transdermal absorption was observed between lidocaine and ibuprofen when Lid·Ibu was applied, possibly indicating different interactions with the tissue components.

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Citations

Oct 26, 2018·Physical Chemistry Chemical Physics : PCCP·Alberto GutiérrezSantiago Aparicio
Oct 26, 2018·Physical Chemistry Chemical Physics : PCCP·Z WojnarowskaM Paluch
Apr 9, 2019·Expert Opinion on Drug Delivery·Sónia N PedroArmando J D Silvestre
May 22, 2019·Advanced Materials·Eden E L TannerSamir Mitragotri
Jun 5, 2019·Pharmaceutics·Mahdi RoohnikanDavide Brambilla
Oct 27, 2018·Current Medicinal Chemistry·Ana Rita DiasRicardo Ferraz
Jul 23, 2020·Anais Da Academia Brasileira De Ciências·Pattwat ManeewattanapinyoJirapornchai Suksaeree
Nov 10, 2020·Organic & Biomolecular Chemistry·Yibiao LiKun Zhang
Nov 11, 2020·International Journal of Molecular Sciences·Sónia N PedroMara G Freire
Jul 11, 2021·Advanced Science·Alexander M CurreriEden E L Tanner
Aug 7, 2021·International Journal of Pharmaceutics·Anita UmerskaLidia Tajber

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