PMID: 9530982Apr 8, 1998Paper

Transdermal delivery and accumulation of indomethacin in subcutaneous tissues in rats

The Journal of Pharmacy and Pharmacology
S A MikulakM E Nimni

Abstract

Oral non-steroidal anti-inflammatory drugs (NSAIDs) are effective pharmacotherapy for a wide variety of painful, inflammatory disorders. Development of an efficient means of topical administration of NSAIDs could increase local soft-tissue and joint concentrations while reducing systemic distribution of the drug, thereby reducing side-effects. With this in mind we studied the effects of a novel topical penetration enhancer for lipophilic compounds, a trans-phase delivery system (TPDS), a solution of benzyl alcohol, isopropanol and acetone, on the distribution of indomethacin in various tissues locally and remote from the site of application. We compared the TPDS with a 50:50 (v/v) mixture of propylene glycol and ethanol, a commonly used penetration enhancer, and with oral administration. We found that the TPDS was significantly superior to the other approaches at achieving high local-tissue concentrations in the vicinity of the site of application. In addition, comparison of these two carrier systems seems to clarify the different aqueous and hydrophobic pathways of drug penetration which emerge from various experimental findings and theoretical considerations. Our results suggest that this non-aqueous solvent system, and benzy...Continue Reading

References

Jan 1, 1979·Drug Metabolism Reviews·D E Duggan, K C Kwan
Apr 1, 1991·The Journal of Pharmacy and Pharmacology·F de VosJ P Remon
May 1, 1991·Journal of Pharmaceutical Sciences·B IllelO Doucet
Oct 1, 1990·The Journal of Pharmacy and Pharmacology·M E NimniR A Oakes
Feb 1, 1991·Chemical & Pharmaceutical Bulletin·K TakahashiN Mizuno
Jan 1, 1990·British Journal of Clinical Pharmacology·H T SchneiderK Brune
Jun 1, 1990·Pharmaceutical Research·M L FrancoeurR O Potts
Feb 1, 1989·The Journal of Pharmacy and Pharmacology·U T LashmarN Thomas
Apr 1, 1989·Chemical & Pharmaceutical Bulletin·F KaihoY Kato
May 1, 1987·The Journal of Investigative Dermatology·A RougierH I Maibach
Jun 1, 1983·The Journal of Dermatology·Y Jimbo
Dec 1, 1983·Journal of Pharmaceutical Sciences·R H Guy, H I Maibach
Jul 1, 1982·Archives of Dermatology·R B Stoughton

❮ Previous
Next ❯

Citations

May 26, 2010·Journal of Materials Science. Materials in Medicine·Xiao-mei WuDeng-guang Yu
Aug 1, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·J RautioT Järvinen
Nov 1, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J ScognamiglioA M Api
Sep 15, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiD K Wilcox
Oct 16, 2004·The Journal of Pharmacy and Pharmacology·Carmelo PugliaFrancesco Bonina
Jul 16, 2005·International Journal of Pharmaceutics·Gihan R NanayakkaraMarc B Brown
Dec 1, 1999·The Journal of Pharmacy and Pharmacology·L Peng, M E Nimni
Oct 1, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang
Oct 18, 2019·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang
Apr 27, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M ApiS Tsang

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.