Abstract
The present study was aimed at unveiling the influence of glycyrrhizin and chitosan on rat epidermis and to correlate these effects with percutaneous permeation characteristics of carvedilol. The permeation of carvedilol across excised rat epidermis was significantly higher (p < 0.05) when glycyrrhizin, chitosan, or glycyrrhizin-chitosan mixture was used as a donor vehicle as compared to propylene glycol:ethanol (7:3) mixture. Epidermis obtained after 12 hr treatment of viable rat skin with a glycyrrhizin-chitosan mixture showed significantly higher (p < 0.05) permeability to carvedilol as compared to that after treatment with glycyrrhizin or chitosan alone. Further, the application of patches containing glycyrrhizin-chitosan mixture resulted in sustained release of carvedilol, which was able to control the hypertension in deoxycorticosterone acetate induced hypertensive rats through 28 hr. Estimation of microconstituents in rat epidermis revealed maximum extraction of cholesterol, sphingosine, and triglycerides after treatment with glycyrrhizin-chitosan mixture. This was manifested in altered lipid and protein-specific thermotropic transitions. Further, increase in intercellular space, disordered lipid structure and corneocyte...Continue Reading
References
Apr 1, 1976·Journal of Ultrastructure Research·R M Lavker
May 1, 1970·Journal of Pharmaceutical Sciences·M Gibaldi, S Feldman
Jun 15, 1993·Biochemical and Biophysical Research Communications·R SabbadiniG Salviati
May 20, 1996·Biochimica Et Biophysica Acta·J A BouwstraM Ponec
Mar 1, 1996·Pharmaceutical Research·M HeisigG Lee
Apr 1, 1997·The Anatomical Record·N YamashitaA Tomita
Aug 1, 1997·Journal of Microscopy·B A Van den BerghJ A Bouwstra
Sep 29, 2001·International Journal of Pharmaceutics·J ShokriM Barzegar Jalali
Sep 5, 2002·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Bhagwant D RegeJames E Polli
Dec 18, 2002·Il Farmaco·A NokhodchiL A S Bahary
Jan 16, 2003·International Journal of Pharmaceutics·A NokhodchiM Barzegar-Jalali
Apr 4, 2003·International Archives of Allergy and Immunology·Yoshinori Mine, Jie Wie Zhang
Dec 1, 1963·Archives of Dermatology·A M KLIGMAN, E CHRISTOPHERS
Feb 27, 2004·Pharmaceutical Research·Jennifer SmithMichael Dornish
Apr 5, 2005·Molecular Pharmaceutics·Kumar Babita, Ashok K Tiwary
Dec 16, 2005·AAPS PharmSciTech·Kumar BabitaAshok K Tiwary
May 23, 2006·Regulatory Peptides·M Khazaei, M Nematbakhsh
Jun 1, 1983·The Journal of Investigative Dermatology·P M Elias
Citations
Feb 25, 2009·AAPS PharmSciTech·Bharti SapraAshok K Tiwary
Oct 6, 2012·Therapeutic Delivery·Sevgi Güngör, Yildiz Ozsoy
Jun 15, 2013·Drug Delivery·Yang ChenLiang Fang
Jan 21, 2016·Drug Delivery·Yatian WangGuofeng Li
Dec 25, 2015·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Abdul AhadMohd Aqil
Jun 25, 2016·Drug Delivery·Laizhu ZhangShilei Wang
Feb 1, 2014·Archives of Dermatological Research·Umesh K Patil, Richa Saraogi
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·A Ligia FocsanLowell D Kispert
Jul 30, 2020·The Journal of Membrane Biology·Yuri I GlazachevNikolay E Polyakov
Sep 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xitong SuPeng Zhang
Mar 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Olga Yu SelyutinaNikolay E Polyakov
Jun 15, 2019·Molecular Pharmaceutics·Alexandra V KimNikolay Z Lyakhov
Aug 29, 2021·Pharmaceuticals·Szymon SipJudyta Cielecka-Piontek