Transdermal delivery of scopolamine by natural submicron injectors: in-vivo study in pig.

PloS One
Esther ShaoulTamar Lotan

Abstract

Transdermal drug delivery has made a notable contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. While transdermal delivery systems would appear to provide an attractive solution for local and systemic drug delivery, only a limited number of drugs can be delivered through the outer layer of the skin. The most difficult to deliver in this way are hydrophilic drugs. The aquatic phylum Cnidaria, which includes sea anemones, corals, jellyfish and hydra, is one of the most ancient multicellular phyla that possess stinging cells containing organelles (cnidocysts), comprising a sophisticated injection system. The apparatus is folded within collagenous microcapsules and upon activation injects a thin tubule that immediately penetrates the prey and delivers its contents. Here we show that this natural microscopic injection system can be adapted for systemic transdermal drug delivery once it is isolated from the cells and uploaded with the drug. Using a topically applied gel containing isolated natural sea anemone injectors and the muscarinic receptor antagonist scopolamine, we found that the formulated injectors could penetrate porcine skin and immedi...Continue Reading

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Citations

Apr 29, 2014·Integrative and Comparative Biology·Leslie S Babonis, Mark Q Martindale
Jun 15, 2017·Electrophoresis·Sinwook ParkGilad Yossifon
Oct 16, 2016·Parasites & Vectors·Jonathan Ben-DavidTamar Lotan
Mar 3, 2017·Journal of the Royal Society, Interface·Sinwook ParkTamar Lotan

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