Transdermal Delivery of Sumatriptan Succinate Using Iontophoresis and Dissolving Microneedles

Journal of Pharmaceutical Sciences
James Paul RonnanderAndreas Koch

Abstract

This study focuses on the in vitro transdermal transport of sumatriptan succinate using combined iontophoresis and dissolving polymeric microneedle arrays. Permeation experiments were performed to evaluate the effects of formulation parameters on drug release from polyvinylpyrrolidone systems under mild electrical current (≤500 μA/cm2). The preparations consisted of hydrophilic, positively charged molecules encapsulated in a water-soluble and biocompatible polymeric material. Current densities of 100, 300, and 500 μA/cm2 were applied during a 6-h period using silver/silver chloride electrodes. The circular array consisted of 600 needles and occupied a 0.785 cm2 area. Tests, carried out with Franz diffusion cells and skin of Göttingen minipigs, showed that small decreases in the polymer concentration led to negligible lag times and marked increases in the cumulative amount of drug permeated in 6 h (Q6h) and in the flux (Jss). At 500 μA/cm2, Q6h and Jss nearly doubled for a microneedle loaded with 5% (w/w) sumatriptan and 20% (w/w) PVP (lag time = 0 min; Q6h = 2888 μg/cm2; Jss = 490 μg/cm2/h) relative to a system loaded with 5% (w/w) drug and 30% (w/w) PVP (lag time = 36 min; Q6h = 1437 μg/cm2; Jss = 266 μg/cm2/h).

Citations

Jan 8, 2020·AAPS PharmSciTech·Kevin Ita, Sharon Ashong
Jul 22, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Mahadevabharath R SomayajiLaurent Simon
Sep 17, 2021·International Journal of Pharmaceutics·Kamchai SaepangDoungdaw Chantasart

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