Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding

International Journal of Pharmaceutics
Aaron R J HuttonRyan F Donnelly

Abstract

Vitamin K deficiency within neonates can result in vitamin K deficiency bleeding. Ensuring that newborns receive vitamin K is particularly critical in places where access to health care and blood products and transfusions is limited. The World Health Organization recommends that newborns receive a 1 mg intramuscular injection of vitamin K at birth. Evidence from multiple surveillance studies shows that the introduction of vitamin K prophylaxis reduces the incidence of vitamin K deficiency bleeding. Despite these recommendations, coverage of vitamin K prophylactic treatment in low-resource settings is limited. An intramuscular injection is the most common method of vitamin K administration in neonates. In low- and middle-income countries, needle sharing may occur, which may result in the spread of bloodborne diseases. The objective of our study was to investigate the manufacture of microneedles for the delivery of vitamin K. Following microneedle fabrication, we performed insertion studies to assess the microneedle's mechanical properties. Results indicate that vitamin K in a microneedle array was successfully delivered in vitro across neonatal porcine skin with 1.80 ± 0.08 mg delivered over 24 h. Therefore, this initial study s...Continue Reading

Citations

Oct 24, 2018·Drug Development and Industrial Pharmacy·Saili DharadharVandana Patravale
Jun 25, 2020·Pharmaceutics·Antonio José GuillotAna Melero
Jul 16, 2019·Obesity Surgery·Shireesh SaurabhNamrata Singh
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Luis Abelardo Villarruel MendozaPaolo Nicolas Catalano
Oct 24, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Parbeen SinghXu Zhang
May 30, 2021·International Journal of Pharmaceutics·Lijing ZhangPeng Zhang
Jul 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Ke PengRyan F Donnelly
Aug 3, 2021·Metabolism Open·Maria G GrammatikopoulouDimitrios P Bogdanos
Aug 2, 2021·Drug Delivery and Translational Research·Aaron R J HuttonRyan F Donnelly

❮ Previous
Next ❯

Methods Mentioned

BETA
infrared
Infrared Spectroscopy

Software Mentioned

Gen5
GraphPad
GraphPad Prism®
TA Texture Analyser

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
Patricia González-VázquezRyan F Donnelly
Paediatrics and International Child Health
J B S Coulter
© 2022 Meta ULC. All rights reserved