PMID: 8605052Dec 1, 1995Paper

Transdermal delivery of zalcitabine: in vitro skin permeation study

AIDS
D D Kim, Y W Chien

Abstract

To study the feasibility of transdermal delivery of anti-HIV drugs in order to maintain blood concentration within the therapeutic range for longer duration and to reduce the side-effects associated with high dose administration. The effects of vehicles and enhancers on the skin permeation rate of zalcitabine (ddC) were investigated to determine the maximum permeation rate attainable. In vitro skin permeation of ddC, saturated in various compositions of ethanol/tricaprylin or ethanol/water cosolvent system, with and without enhancer, was studied at 37 degrees C using freshly excised hairless rat skin and human cadaver skin as model skins. The skin permeation rate of ddC from both ethanol/tricaprylin and ethanol/water cosolvent system increased when increasing the volume fraction of ethanol and reached maximum values at 50-60% (vol/vol) of ethanol. Addition of 1.0% (vol/vol) of permeation enhancer, such as oleic acid or N-methyl-2-pyrrolidone, to the ethanol/tricaprylin (50:50) cosolvent system could not significantly increase the permeation rate of ddC. However, addition of 1.0% (vol/vol) of oleic acid in ethanol/water (60:40) cosolvent system dramatically enhanced the skin permeation rate of ddC with reduced lag time. Permeati...Continue Reading

Citations

Dec 3, 1998·Pharmaceutical Development and Technology·S A GiannakouN H Choulis
Jun 26, 2009·Expert Opinion on Therapeutic Patents·Abdul AhadSushama Talegaonkar
Nov 9, 2000·Drug Development and Industrial Pharmacy·V R Sinha, M P Kaur
May 24, 2007·Drug Development and Industrial Pharmacy·Rashmi A ThakurVictor M Meidan
Jul 29, 2008·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Elizabeth OjewoleThirumala Govender
Aug 29, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pankaj KarandeSamir Mitragotri
Nov 14, 2012·Biomaterials·Xiaojuan KhooDaniel S Kohane
Feb 19, 2015·Therapeutic Delivery·Anthony S Ham, Robert W Buckheit
Nov 17, 2007·International Journal of Pharmaceutics·Minja GerberJeanetta du Plessis

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