Transdermal drug delivery: feasibility for treatment of superficial bone stress fractures

Drug Delivery and Translational Research
Ali Aghazadeh-HabashiMichael R Doschak

Abstract

Transdermal drug delivery offers the promise of effective drug therapy at selective sites of pathology whilst reducing systemic exposure to the pharmaceutical agents in off-target organs and tissues. However, that strategy is often limited to cells comprising superficial tissues of the body (rarely to deeper bony structures) and mostly indicated with small hydrophobic pharmacological agents, such as steroid hormones and anti-inflammatory gels to skin, muscle, and joints. Nonetheless, advances in transdermal liposomal formulation have rendered the ability to readily incorporate pharmacologically active hydrophilic drug molecules and small peptide biologics into transdermal dosage forms to impart the effective delivery of those bioactive agents across the skin barrier to underlying superficial tissue structures including bone, often enhanced by some form of electrical, chemical, and mechanical facilitation. In the following review, we evaluate transdermal drug delivery systems, with a particular focus on delivering therapeutic agents to treat superficial bone pain, notably stress fractures. We further introduce and discuss several small peptide hormones active in bone (such as calcitonins and parathyroid hormone) that have shown ...Continue Reading

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Citations

Jun 23, 2015·The Veterinary Journal·Jörg A Auer, David W Grainger
Dec 31, 2017·Drug Delivery and Translational Research·Maria Natalia CalienniJorge Montanari
Jan 8, 2021·Expert Opinion on Drug Delivery·Nikita NirwanDivya Vohora

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