Mar 15, 2016

Transdermal electrical neuromodulation of the trigeminal sensory nuclear complex improves sleep quality and mood.

BioRxiv : the Preprint Server for Biology
Alyssa M BoassoWilliam J Tyler


Achieving optimal human performance that involves cognitive or physical work requires quality sleep and a positive mental attitude. The ascending reticular activating system (RAS) represents a powerful set of endogenous neuromodulatory circuits that gate and tune global brain responses to internal and external cues, thereby regulating consciousness, alertness, and attention. The activity of two major RAS nuclei, the locus coeruleus (LC) and pedunculopontine nucleus (PPN), can be altered by trigeminal nerve modulation. Monosynaptic afferent inputs from the sensory components of trigeminal nerve branches project to the trigeminal sensory nuclear complex (TSNC), which has direct and polysynaptic connections to the LC and PPN. We previously found high-frequency (7 - 11 kHz) transdermal electrical neuromodulation (TEN) of the trigeminal nerve rapidly induces physiological relaxation, dampens sympathetic nervous system responses to acute stress, and suppresses levels of noradrenergic biomarkers. Given the established roles of LC and PPN neuronal activity in sleep regulation, psychophysiological arousal, and stress, we conducted three studies designed to test hypotheses that modulation of the TSNC can improve sleep quality and mood in...Continue Reading

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Mentioned in this Paper

Biological Markers
Cervical Spinal Nerve
Salicylhydroxamic acid
Sympathetic Nervous System
ras Oncogene
Pedunculopontine Tegmental Nucleus
Reticular Activating System
Entire Cervical Nerves

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