PMID: 12780842Jun 5, 2003Paper

Transdermal electromotive administration of verapamil and dexamethasone for Peyronie's disease

BJU International
Savino M Di StasiGiuseppe Vespasiani

Abstract

To evaluate the effects of the transdermal electromotive administration of verapamil and dexamethasone on plaque size, penile deviation, pain, erectile function and capacity for vaginal penetration in patients with Peyronie's disease. Forty-nine patients were treated four times weekly for six consecutive weeks. During each session the drug mixture was administered from a receptacle fixed to the skin overlying the plaques, using 2.4 mA pulsed current for 20 min. Plaque size and penile deviation were evaluated by dynamic penile duplex ultrasonography, X-ray and photographs; pain, erectile function and capacity for vaginal penetration were assessed using a questionnaire. Vital signs and side-effects were recorded. Differences before and after treatment were assessed. The plaque disappeared in 8% of patients, with a measurable reduction in volume in 74% and no change in 18% (P < 0.001). Penile deviation resolved in 10% of the men, decreased in 74% and remained unchanged in 16% (P < 0.001). The plaque volume was halved in two-thirds of the men, to a mean (sd) of 515 (301) mm3, and the penile deviation halved in 45% of patients, to 24 (5) degrees; pain was completely eliminated in 88% (P < 0.001). Erectile function was completely res...Continue Reading

References

Dec 1, 1990·The Journal of Urology·M K GelbardK James
Nov 1, 1990·The Journal of Surgical Research·R C Lee, J A Ping
Jan 1, 1970·The Journal of Urology·J L Williams, G G Thomas
May 1, 1967·The Journal of Urology·S H Rothfeld, W Murray
Jan 1, 1983·Urologia Internationalis·A Kelâmi
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·M RothL H Block
Jan 1, 1997·The Journal of Urology·C J DevineS M Schlossberg
Dec 22, 1999·The Journal of Urology·C R RiedlH Pflüger
Mar 14, 2002·BJU International·U SchwarzerU Engelmann
Jul 20, 2002·The Journal of Urology·Laurence A LevineJason M Greenfield
Aug 1, 2001·World Journal of Urology·Hari Siva Gurunadha Rao Tunuguntla

❮ Previous
Next ❯

Citations

Aug 6, 2011·Current Urology Reports·Ege Can Serefoglu, Wayne J G Hellstrom
Sep 16, 2011·International Journal of Impotence Research·S M Larsen, L A Levine
Dec 19, 2007·Asian Journal of Andrology·Frederick L Taylor, Laurence A Levine
Nov 5, 2013·The Urologic Clinics of North America·Ashley H Tapscott, Lawrence S Hakim
Sep 8, 2009·The Journal of Sexual Medicine·James F SmithTom F Lue
Jan 21, 2006·The Journal of Sexual Medicine·John PryorWalter Stackl
Mar 5, 2016·Indian Journal of Urology : IJU : Journal of the Urological Society of India·Aylin N Bilgutay, Alexander W Pastuszak
May 31, 2011·The Urologic Clinics of North America·Stephen M Larsen, Laurence A Levine
Nov 7, 2007·The Urologic Clinics of North America·Frederick L Taylor, Laurence A Levine
Nov 18, 2005·The Urologic Clinics of North America·Jason M Greenfield, Laurence A Levine
Aug 19, 2015·Current Sexual Health Reports·Aylin N Bilgutay, Alexander W Pastuszak
Feb 10, 2010·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·O AlendaM Rouprêt
Mar 1, 2008·Expert Review of Clinical Pharmacology·Jason M Greenfield
Nov 7, 2018·Nature Reviews. Urology·Peter Tsambarlis, Laurence A Levine

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.