Transdermal fentanyl versus sustained-release oral morphine in cancer pain: preference, efficacy, and quality of life. The TTS-Fentanyl Comparative Trial Group

Journal of Pain and Symptom Management
S Ahmedzai, D Brooks

Abstract

Cancer patients requiring strong opioid analgesia (n = 202; mean age, 61.5 years; range, 18-89 years; 55% men) were recruited from 38 United Kingdom palliative care centers into a randomized, open, two-period, crossover study comparing transdermal fentanyl with sustained-release oral morphine. Patients received one treatment for 15 days followed immediately by the other for 15 days. Daily diaries were completed. Both treatments appeared equally effective in terms of pain control, as assessed by the Memorial Pain Assessment Card and European Organization for Research and Treatment of Cancer (EORTC) pain scores. Fentanyl was associated with significantly less constipation (p < 0.001) and less daytime drowsiness (p = 0.015) but greater sleep disturbance (p = 0.004) and shorter sleep duration (p = 0.008) than morphine. The World Health Organization (WHO) performance status and EORTC global quality of life scores showed no significant difference between treatment groups. Of those patients who were able to express a preference (n = 136), significantly more preferred the fentanyl patches (p = 0.037). We conclude that, in this study, transdermal fentanyl provided pain relief that was acceptable to cancer patients and was associated wit...Continue Reading

References

Jan 1, 1994·Journal of Pain and Symptom Management·M ZenzM Strumpf
Jul 1, 1995·Journal of Pain and Symptom Management·N D de StoutzM Suarez-Almazor
Jan 1, 1995·Journal of Pain and Symptom Management·C M Higgs, J Vella-Brincat
Apr 22, 1995·BMJ : British Medical Journal·F LarueC S Cleeland
Jan 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S Ahmedzai

❮ Previous
Next ❯

Citations

Mar 21, 2002·The Lancet Oncology·G K Gourlay
Feb 26, 2004·Southern Medical Journal·Peter S StaatsJeffrey Schein
Jun 1, 2002·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Lukas RadbruchG Nuyts
May 21, 1999·Lancet·R K Portenoy, P Lesage
Jan 1, 2011·Case Reports in Medicine·Naomi KishineTomohisa Shoko
Mar 24, 2006·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Stacey J AckermanPeter Staats
Oct 10, 2012·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Joseph A WoelfelSian M Carr-Lopez
Feb 18, 2006·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Carla RipamontiFranco De Conno
Feb 10, 2012·World Journal of Urology·Pia BaderJan H Vranken
Jan 16, 2015·Biological & Pharmaceutical Bulletin·Takahiro HayashiShigeki Yamadaa
May 23, 2001·Journal of Pain and Symptom Management·M NugentS H Ahmedzai
Nov 6, 1998·Journal of Pain and Symptom Management·P L DellemijnJ A Vanneste
May 15, 2002·Critical Reviews in Oncology/hematology·Marcello De CiccoCristina Santantonio
Mar 9, 2004·Der Schmerz·A SchwarzerE Klaschik
Jul 1, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S Ahmedzai
Oct 17, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S Kaasa, F De Conno
Mar 13, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·N I Cherny
Aug 1, 2013·Current Gastroenterology Reports·Gyanprakash A KetwarooAnthony Lembo
Mar 25, 2008·Therapeutics and Clinical Risk Management·Mario MandalàSandro Barni
Oct 14, 2004·Rheumatology International·Gabriel Herrero-BeaumontUte Richarz
Jan 15, 2003·Current Pain and Headache Reports·Eric Chevlen
Apr 12, 2011·Current Pain and Headache Reports·Wojciech Leppert
Jul 26, 2013·Japanese Journal of Clinical Oncology·Takashi YamaguchiUNKNOWN Japanese Society of Palliative Medicine
Feb 21, 2002·Neurologic Clinics·A C Carver, K M Foley
Jun 18, 2002·Journal of the American Geriatrics Society·UNKNOWN AGS Panel on Persistent Pain in Older Persons
Apr 1, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Yoshiyuki HoyaKatsuhiko Yanaga
Aug 19, 2009·Der Internist·D Rothstein, M Zenz
Sep 12, 2002·Pharmacotherapy·Heather KokkoLawrence B Afrin
Feb 12, 2002·Pharmacotherapy·Christopher M HerndonPamala A Hallin
Jul 23, 2002·Journal of Palliative Medicine·David J CasarettKaren B Hirschman
Jul 22, 2004·Journal of Palliative Medicine·Claudia Bausewein, Irene J Higginson
Feb 28, 2006·Journal of Palliative Medicine·David Casarett
Dec 22, 2007·Journal of Palliative Medicine·James F Cleary
Oct 8, 2009·Journal of Palliative Medicine·Eric Prommer
Apr 21, 2004·The Keio Journal of Medicine·Lukas Radbruch, Frank Elsner
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Michael A AshburnSusan V Basta
Nov 19, 2003·The Journal of Pain : Official Journal of the American Pain Society·Kyriaki MystakidouLambros Vlahos
Sep 30, 2000·Advances in Therapy·S D Passik, H J Weinreb
Jul 14, 2009·International Journal of Clinical Oncology·Takanori MatsuiJunichi Sakamoto

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.