Transdermal immunization of P. falciparum surface antigen (MSP-119) via elastic liposomes confers robust immunogenicity

Human Vaccines & Immunotherapeutics
Rajeev K TyagiAmit Awasthi

Abstract

As transdermal immunization results in poor immunogenicity, which is attributed to poor permeability of antigens through the skin, we believed ultradeformable lipid vesicles (elastic liposome) might address the challenges encountered during transdermal immunization. The elastic liposome, versatile carrier, proves better vehicle for transcutaneous delivery of protein, peptide and nucleic acid antigens. Our recently published article (1) is suggestive of improved immunogenicity of carboxyl-terminal 19 kDa fragment of merozoite surface protein-1 (PfMSP-119) of Plasmodium falciparum when administered subcutaneously via elastic liposomes ( Fig. 1 ).

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Citations

Sep 25, 2017·Expert Review of Vaccines·Hanadi SalibaSoulaima Chamat
Oct 17, 2019·Pharmaceutics·Veena VijayanIn-Kyu Park
Feb 24, 2019·Pharmaceutics·Nadezhda KnauerEvgeny Apartsin
Jul 29, 2021·Malaria Journal·Patrick B Memvanga, Christian I Nkanga

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