Transdermal insulin delivery using choline-based ionic liquids (CAGE)

Journal of Controlled Release : Official Journal of the Controlled Release Society
Eden E L TannerSamir Mitragotri

Abstract

Transdermal delivery of pharmaceuticals using ionic liquids and deep eutectic solvents (DES) has attracted significant interest due to the inherent tunability of the molecules and their capacity to transport large molecules across the skin. Several key properties of DESs including viscosity, miscibility and possible transport enhancement can be controlled through the choice of ions and their ratio in DES. Herein we investigate the effect of cation/anion ratio using Choline and Geranic acid (CAGE) based DES. We synthesized variants of CAGE by controlling the ratio of Choline to Geranic acid over a range of 1:4 to 2:1. Physicochemical properties including viscosity, conductivity and diffusivity were measured. Effect of CAGE on skin permeability was assessed using insulin in ex vivo porcine skin. Each variant was found to have distinct properties, including interionic interactions, viscosity, and conductivity. In addition, the effect of CAGE on stratum corneum lipids, as assessed by FTIR, was dependent on its composition. Transport enhancement was also composition-dependent, as the variants containing excess geranic acid (1:2 and 1:4, but not geranic acid alone) exhibited higher insulin delivery into the dermis compared to other c...Continue Reading

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Citations

May 22, 2019·Advanced Materials·Eden E L TannerSamir Mitragotri
Jun 22, 2019·Chemical Society Reviews·Joana M GomesRui L Reis
Aug 1, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiangfei HanZhiqiang Cao
Jan 8, 2020·Expert Opinion on Drug Delivery·Andrej KováčikKateřina Vávrová
Sep 19, 2019·PloS One·Joshua R GreeneAndrew T Koppisch
Sep 17, 2020·Biophysics Reviews·Pallavi KumariAntonio Benedetto
Aug 25, 2020·Science Advances·Abhirup MandalSamir Mitragotri
Dec 29, 2019·Scientific Reports·Tadashi HattoriYasunori Iwao
Nov 8, 2018·Proceedings of the National Academy of Sciences of the United States of America·Amrita BanerjeeSamir Mitragotri
Dec 9, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jennifer A KistGary A Baker
Aug 27, 2019·European Journal of Pharmacology·Rubiya KhursheedKamal Dua
Jan 5, 2021·ACS Biomaterials Science & Engineering·Junpei TakedaYukihiro Ikeda
Feb 12, 2021·Science Translational Medicine·Hassan AlbadawiRahmi Oklu
Nov 19, 2020·Advanced Healthcare Materials·Yujie ShiSamir Mitragotri
Jan 29, 2021·Science Translational Medicine·Caitlin L MaikawaEric A Appel
Feb 14, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Akel F KanaanAna M A Dias
Feb 10, 2021·Scientific Reports·Akira MinamiTakashi Suzuki
Dec 29, 2020·Nanomedicine·Mariana AmaralCatarina Pinto Reis
Apr 4, 2021·International Journal of Molecular Sciences·Akira MinamiTakashi Suzuki
Apr 29, 2021·Drug Delivery and Translational Research·Soo Chin Yeoh, Choon Fu Goh
May 14, 2021·ACS Biomaterials Science & Engineering·Zongmin ZhaoSamir Mitragotri
Jul 11, 2021·Advanced Science·Alexander M CurreriEden E L Tanner
May 30, 2021·Advanced Healthcare Materials·Kevin PengSamir Mitragotri
Aug 18, 2021·Biomaterials·Mayuka NakajimaSamir Mitragotri
Jul 8, 2019·ACS Biomaterials Science & Engineering·Eden E L TannerSamir Mitragotri
Aug 24, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiying WuJianping Qi
Aug 31, 2021·ACS Applied Materials & Interfaces·Md Rafiqul IslamMasahiro Goto
Sep 4, 2021·Drug Delivery and Translational Research·Lijuan ZengWenting Song

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