PMID: 8587053Nov 1, 1995Paper

Transdermal iontophoresis and solute penetration across excised human skin

Journal of Pharmaceutical Sciences
P SinghH I Maibach

Abstract

The potential of transdermal iontophoresis to facilitate drug delivery was evaluated by studying the transport kinetics of model compounds salicylate (anion), phenylethylamine (cation), mannitol (polar neutral compound of low molecular weight), and inulin (polar neutral compound of high molecular weight) using an excised human skin model. The transport kinetics of solutes were determined across both intact and cellophane-tape-stripped dermatomed skin both in the presence and absence of applied current to probe the mechanisms of iontophoretic delivery. Iontophoresis effectively enhanced delivery of all compounds relative to passive transport. The skin is shown to be both ion selective and size selective. On the basis of results from present work and other studies, the "aqueous pathway" of iontophoretic transport is further reinforced.

Citations

Nov 7, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Narasimha MurthySek Wen Hui
Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Honggang ZhuWilliam I Higuchi
Apr 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Honggang ZhuS Kevin Li
Aug 23, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·S Kevin LiMatthew S Hastings
Mar 11, 1999·Drug Development and Industrial Pharmacy·T S SahotaP M Taylor
Mar 22, 2014·Journal of Pharmaceutical Sciences·Prashanth MandaS Narasimha Murthy
Feb 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Adina C HirschAjay K Banga
May 1, 1997·Placenta·F J LinR S Tuan
Mar 20, 2015·The Journal of Toxicological Sciences·Tomomi AtobeHirokazu Kouzuki

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