Sep 12, 2015

Transdermal neuromodulation of noradrenergic activity suppresses psychophysiological and biochemical stress responses in humans

Scientific Reports
William J TylerSumon K Pal

Abstract

We engineered a transdermal neuromodulation approach that targets peripheral (cranial and spinal) nerves and utilizes their afferent pathways as signaling conduits to influence brain function. We investigated the effects of this transdermal electrical neurosignaling (TEN) method on sympathetic physiology under different experimental conditions. The TEN method involved delivering high-frequency pulsed electrical currents to ophthalmic and maxillary divisions of the right trigeminal nerve and cervical spinal nerve afferents. Under resting conditions, TEN significantly suppressed basal sympathetic tone compared to sham as indicated by functional infrared thermography of facial temperatures. In a different experiment, subjects treated with TEN reported significantly lower levels of tension and anxiety on the Profile of Mood States scale compared to sham. In a third experiment when subjects were experimentally stressed TEN produced a significant suppression of heart rate variability, galvanic skin conductance, and salivary α-amylase levels compared to sham. Collectively these observations demonstrate TEN can dampen basal sympathetic tone and attenuate sympathetic activity in response to acute stress induction. Our physiological and ...Continue Reading

Mentioned in this Paper

Cervical Spinal Nerve
Nervousness
Biological Adaptation to Stress
Salicylhydroxamic acid
Sensory Nerve
Reaction Time
Sympathetic Nervous System
Research Subject
TENC1 protein, human
Maxilla

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