Transdermal nicotine patch failed to improve postoperative pain management

Anesthesia and Analgesia
Alparslan TuranChristian C Apfel

Abstract

A single 3 mg intranasal dose of nicotine has been reported to have analgesic properties. We designed placebo-controlled study to test the hypothesis that transdermal nicotine (TDN) administered over a 3-day period would decrease postoperative pain and opioid analgesic usage and improve the recovery process after lower abdominal surgery. Ninety-seven patients undergoing abdominal hysterectomy procedures were randomly assigned to one of two treatment groups: (1) control group received inert (sham) patches 1 h before and for 2 days after surgery, or the (2) nicotine group received TDN 30 (21 mg nicotine) patches 1 h before induction of anesthesia and for two additional days after surgery. The anesthetic technique was identical in both groups, and the postoperative assessments included verbal rating scales for pain and sedation, IV patient-controlled analgesia morphine usage, quality of recovery assessment, recovery of bowel function, resumption of normal activities, and patient satisfaction with their pain management. Follow-up evaluations were performed at 1 and 3 mo after the operation to assess late recovery events. Postoperative patient-controlled analgesia morphine usage and pain scores while supine or sitting up, intraopera...Continue Reading

References

Jan 1, 1989·Psychopharmacology·J Gross, M L Stitzer
Dec 24, 1996·Proceedings of the National Academy of Sciences of the United States of America·S C HeinrichsE B De Souza
May 5, 1998·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·S GreenlandS F Lanes
Feb 13, 2001·Pharmacology, Biochemistry, and Behavior·R V FantD P Reitberg
Feb 14, 2002·Pharmacology, Biochemistry, and Behavior·J A Dani, M De Biasi
Nov 19, 2002·Journal of Neurobiology·Nicolas Le NovèreJean-Pierre Changeux
Feb 3, 2004·Current Topics in Medicinal Chemistry·Michael W DeckerR Scott Bitner
Nov 27, 2004·Anesthesiology·Pamela Flood, Danette Daniel
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Fernando BerrenderoRafael Maldonado
Mar 26, 2005·Archives of Pharmacal Research·Ki-Jung HanHong-Won Suh
Aug 13, 2005·Neuroscience Letters·Christopher T SimonsE Carstens
Apr 22, 2006·Brain : a Journal of Neurology·Laura L Boles Ponto
May 30, 2006·Brain Research·Vera Combs CampbellYousef Tizabi
Jul 28, 2006·Anesthesiology·Victor Y ChengBeverley A Orser
Feb 22, 2007·Anesthesia and Analgesia·Paul F White, Henrik Kehlet

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Citations

Jun 22, 2010·Obesity Surgery·Toby N WeingartenDavid O Warner
May 8, 2013·European Journal of Pharmacology·Lorenzo Di Cesare MannelliCarla Ghelardini
Nov 1, 2011·The Journal of Pain : Official Journal of the American Pain Society·Anne E SandersGary D Slade
Dec 18, 2009·The Journal of Pain : Official Journal of the American Pain Society·Henrietta L LoganWilliam M Mendenhall
Jul 23, 2016·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Han-Liang ChiangChen-Hsiu Chen
Sep 14, 2015·Revista brasileira de anestesiologia·Asutay GoktugHulya Basar
Sep 2, 2015·Brazilian Journal of Anesthesiology·Asutay GoktugHulya Basar
Mar 1, 2015·Neuropharmacology·Dimitris N XanthosPetra Scholze
Feb 28, 2017·Anaesthesia Critical Care & Pain Medicine·Sébastien PierreBertrand Dureuil
Jan 13, 2016·The Cochrane Database of Systematic Reviews·Annette M MatthewsRoger Chou
May 13, 2011·European Journal of Anaesthesiology·Christopher J JankowskiJuraj Sprung
Sep 25, 2010·Anesthesiology·Yu ShiDavid O Warner
May 5, 2012·Anesthesia and Analgesia·Edward J Mascha, Alparslan Turan
Aug 21, 2008·Anesthesia and Analgesia·Neal L Benowitz
Jan 5, 2014·Anesthesia and Analgesia·Basem M Mishriky, Ashraf S Habib
Aug 1, 2012·Anesthesiology·Christian C ApfelAnthony Kovac

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