Abstract
Elevated frontal and striatal reactivity to drug cues is a transdiagnostic hallmark of substance use disorders. The goal of these experiments was to determine if it is possible to decrease frontal and striatal reactivity to drug cues in both cocaine users and heavy alcohol users through continuous theta burst stimulation (cTBS) to the left ventromedial prefrontal cortex (VMPFC). Two single-blinded, within-subject, active sham-controlled experiments were performed wherein neural reactivity to drug/alcohol cues versus neutral cues was evaluated immediately before and after receiving real or sham cTBS (110% resting motor threshold, 3600 pulses, Fp1 location; N = 49: 25 cocaine users [experiment 1], 24 alcohol users [experiment 2]; 196 total functional magnetic resonance imaging scans). Generalized psychophysiological interaction and three-way repeated-measures analysis of variance were used to evaluate cTBS-induced changes in drug cue-associated functional connectivity between the left VMPFC and eight regions of interest: ventral striatum, left and right caudate, left and right putamen, left and right insula, and anterior cingulate cortex. In both experiments, there was a significant interaction between treatment (real/sham) and t...Continue Reading
Citations
Jan 8, 2019·Addiction Biology·Guangheng DongMarc N Potenza
Jun 18, 2019·Clinical Pharmacology and Therapeutics·Colleen A HanlonTonisha Kearney Ramos
Jul 23, 2019·Addiction·Jack J Q ZhangGeorg S Kranz
Aug 28, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Noah S PhilipColleen A Hanlon
Feb 28, 2020·Psychological Medicine·Guang-Heng DongMarc N Potenza
Jan 9, 2020·The Journal of ECT·Mauro PettorrusoMassimo di Giannantonio
Nov 15, 2019·Journal of Addiction Medicine·Mauro PettorrusoGeorge F Koob
Oct 9, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Colleen A Hanlon
Dec 22, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Brandon G OberlinDavid A Kareken
Jan 11, 2020·Frontiers in Psychiatry·Antonio Verdejo-GarciaHamed Ekhtiari
Mar 27, 2020·Frontiers in Neuroscience·Jessica MorettiJennifer Rodger
Aug 14, 2019·Frontiers in Neuroscience·Angela SannaMarco Diana
Apr 17, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yuzheng HuYihong Yang
May 28, 2019·Frontiers in Psychiatry·Tonisha E Kearney-RamosColleen A Hanlon
Dec 12, 2018·Frontiers in Neuroscience·Di ZhaoTifei Yuan
Nov 21, 2020·The American Journal of Drug and Alcohol Abuse·Yong Shen, Heather Burrell Ward
Nov 21, 2020·Journal of Psychiatry and Brain Science·Daniel SazhinDavid V Smith
Oct 23, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Yijie ZhaoChencheng Zhang
Mar 19, 2021·Journal of Psychiatry and Brain Science·Marta PeciñaHelmet T Karim
Apr 1, 2021·Journal of Neurotrauma·Jeremy HogeveenDavin K Quinn