Transdiagnostic time-varying dysconnectivity across major psychiatric disorders.

Human Brain Mapping
Chao LiKe Xu

Abstract

Dynamic functional connectivity (DFC) analysis can capture time-varying properties of connectivity. However, studies on large samples using DFC to investigate transdiagnostic dysconnectivity across schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) are rare. In this study, we used resting-state functional magnetic resonance imaging and a sliding-window method to study DFC in a total of 610 individuals (150 with SZ, 100 with BD, 150 with MDD, and 210 healthy controls [HC]) at a single site. Using k-means clustering, DFCs were clustered into three functional connectivity states: one was a more frequent state with moderate positive and negative connectivity (State 1), and the other two were less frequent states with stronger positive and negative connectivity (State 2 and State 3). Significant 4-group differences (SZ, BD, MDD, and HC groups; q < .05, false-discovery rate [FDR]-corrected) in DFC were nearly only in State 1. Post hoc analyses (q < .05, FDR-corrected) in State 1 showed that transdiagnostic dysconnectivity patterns among SZ, BD and MDD featured consistently decreased connectivity within most networks (the visual, somatomotor, salience and frontoparietal networks), which was most obvious in ...Continue Reading

References

Jun 30, 2001·The American Journal of Psychiatry·W M PerlsteinJ D Cohen
Jun 9, 2005·Archives of General Psychiatry·Ronald C KesslerEllen E Walters
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Dec 15, 2007·Biostatistics·Jerome FriedmanRobert Tibshirani
Feb 6, 2008·Archives of General Psychiatry·Avram J Holmes, Diego A Pizzagalli
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Jul 10, 2009·Nature·Ilina Singh, Nikolas Rose
Sep 8, 2010·NeuroImage·Stephen M SmithMark W Woolrich
Sep 24, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Diego A Pizzagalli
Dec 17, 2010·Human Brain Mapping·Erik Barry ErhardtVince D Calhoun
Jun 4, 2011·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Radek Ptak
Jun 10, 2011·Journal of Neurophysiology·B T Thomas YeoRandy L Buckner
Aug 4, 2011·NeuroImage·Koene R A Van DijkRandy L Buckner
Oct 2, 2012·Annual Review of Psychology·Adele Diamond
Nov 14, 2012·Cerebral Cortex·Elena A AllenVince D Calhoun
Mar 5, 2013·Lancet·UNKNOWN Cross-Disorder Group of the Psychiatric Genomics Consortium
Apr 26, 2013·Human Brain Mapping·Ling-Li ZengDewen Hu
May 16, 2013·BMC Medicine·Bruce N Cuthbert, Thomas R Insel
May 28, 2013·NeuroImage·R Matthew HutchisonCatie Chang
Jul 5, 2013·Cerebral Cortex·Alan AnticevicDavid C Glahn
Jul 31, 2013·Nature Neuroscience·Michael W ColeTodd S Braver
Aug 13, 2013·Nature Genetics·UNKNOWN Cross-Disorder Group of the Psychiatric Genomics ConsortiumUNKNOWN International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)
Sep 26, 2013·Journal of Neurodevelopmental Disorders·Nava Levit-BinnunYulia Golland
Oct 17, 2013·Trends in Cognitive Sciences·Theodore P Zanto, Adam Gazzaley
Mar 29, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rebecca K SripadaIsrael Liberzon
Oct 3, 2014·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Deanna M Barch, Julia M Sheffield
Nov 2, 2014·Clinical Psychological Science : a Journal of the Association for Psychological Science·Avshalom CaspiTerrie E Moffitt
Jan 13, 2015·Annual Review of Clinical Psychology·Godfrey D Pearlson
Feb 5, 2015·JAMA Psychiatry·Madeleine GoodkindAmit Etkin
May 2, 2015·Science·Thomas R Insel, Bruce N Cuthbert
Nov 1, 2011·Perspectives on Psychological Science : a Journal of the Association for Psychological Science·Susan Nolen-Hoeksema, Edward R Watkins
Apr 15, 2016·Neuroinformatics·Chao-Gan YanYu-Feng Zang
Aug 12, 2016·Proceedings of the National Academy of Sciences of the United States of America·Chenhao WangMichael W L Chee
Mar 23, 2017·The American Journal of Psychiatry·Lisa M McTeagueAmit Etkin
May 27, 2017·Brain : a Journal of Neurology·Masud Husain
Oct 21, 2017·Brain : a Journal of Neurology·Jinhee KimAntonio P Strafella

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

SPM12
GIFT

Related Concepts

Related Feeds

Bipolar Disorder

Bipolar disorder is characterized by manic and/or depressive episodes and associated with uncommon shifts in mood, activity levels, and energy. Discover the latest research this illness here.