Transdiagnostic variations in impulsivity and compulsivity in obsessive-compulsive disorder and gambling disorder correlate with effective connectivity in cortical-striatal-thalamic-cortical circuits

NeuroImage
Linden ParkesMurat Yücel

Abstract

Individual differences in impulsivity and compulsivity is thought to underlie vulnerability to a broad range of disorders and are closely tied to cortical-striatal-thalamic-cortical function. However, whether impulsivity and compulsivity in clinical disorders is continuous with the healthy population and explains cortical-striatal-thalamic-cortical dysfunction across different disorders remains unclear. Here, we characterized the relationship between cortical-striatal-thalamic-cortical effective connectivity, estimated using dynamic causal modelling of resting-state functional magnetic resonance imaging data, and dimensional phenotypes of impulsivity and compulsivity in two symptomatically distinct but phenotypically related disorders, obsessive-compulsive disorder and gambling disorder. 487 online participants provided data for modelling of dimensional phenotypes. These data were combined with 34 obsessive-compulsive disorder patients, 22 gambling disorder patients, and 39 healthy controls, who underwent functional magnetic resonance imaging. Three core dimensions were identified: disinhibition, impulsivity, and compulsivity. Patients' scores on these dimensions were continuously distributed with the healthy participants, supp...Continue Reading

Citations

Sep 3, 2020·Scientific Reports·Jeggan TiegoMurat Yücel
Sep 13, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rafa Romero-GarciaSamuel R Chamberlain
Oct 30, 2020·Neuroscience and Biobehavioral Reviews·Roxanne W HookSamuel R Chamberlain
Jun 12, 2021·Journal of Neuroscience Research·Geoffrey de BrouwerDe Wet Wolmarans
Feb 9, 2021·Annual Review of Neuroscience·Claire M Gillan, Robb B Rutledge

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