Transdifferentiation is a driving force of regeneration in Halisarca dujardini (Demospongiae, Porifera)

PeerJ
Ilya E BorisenkoAlexander V Ereskovsky

Abstract

The ability to regenerate is widespread in the animal kingdom, but the regenerative capacities and mechanisms vary widely. To understand the evolutionary history of the diverse regeneration mechanisms, the regeneration processes must be studied in early-evolved metazoans in addition to the traditional bilaterian and cnidarian models. For this purpose, we have combined several microscopy techniques to study mechanisms of regeneration in the demosponge Halisarca dujardini. The objectives of this work are to detect the cells and morphogenetic processes involved in Halisarca regeneration. We show that in Halisarca there are three main sources of the new exopinacoderm during regeneration: choanocytes, archaeocytes and (rarely) endopinacocytes. Here we show that epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) occur during Halisarca regeneration. EMT is the principal mechanism during the first stages of regeneration, soon after the injury. Epithelial cells from damaged and adjacent intact choanocyte chambers and aquiferous canals assume mesenchymal phenotype and migrate into the mesohyl. Together with archaeocytes, these cells form an undifferentiated cell mass beneath of wound, which we refer...Continue Reading

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Citations

Feb 13, 2016·Journal of Experimental Zoology. Part A, Ecological Genetics and Physiology·Andrey I Lavrov, Igor A Kosevich
Jun 12, 2016·BMC Evolutionary Biology·Ilya BorisenkoMaja Adamska
Jun 20, 2016·Current Opinion in Genetics & Development·Maja Adamska
Oct 8, 2016·Microscopy Research and Technique·Yaroslav O Kamenev, Igor Y Dolmatov
May 3, 2018·Wiley Interdisciplinary Reviews. Developmental Biology·Lorenzo Ricci, Mansi Srivastava
Nov 15, 2019·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Alexander V EreskovskyAndrey I Lavrov
Aug 8, 2019·Cell and Tissue Research·Patrick R H Steinmetz
Nov 14, 2018·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Andrey I LavrovAlexander V Ereskovsky
Aug 23, 2020·Cells·Letizia ZulloSimona Candiani
Jun 12, 2020·PeerJ·Natalia Shunatova, Ilya Borisenko
Aug 28, 2021·International Journal of Molecular Sciences·Kim I AdameykoYulia V Lyupina
Oct 8, 2021·Biological Reviews of the Cambridge Philosophical Society·Baruch RinkevichBert Hobmayer
Oct 12, 2021·Cell and Tissue Research·Kalacheva Nadezhda VDolmatov Igor Yu

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Methods Mentioned

BETA
light microscopy
dissections
transmission electron microscopy
scanning electron microscopy
amputation

Software Mentioned

ImageJ

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