PMID: 7520878Aug 1, 1994Paper

Transdifferentiation of embryonic and postnatal rabbit corneal epithelial cells

Differentiation; Research in Biological Diversity
C FerrarisD Dhouailly

Abstract

In order to study the determination of corneal epithelial cells, rabbit corneal epithelium of 12- to 24-day embryos, newborn and 12-day-old offspring were recombined with mouse embryo upper-lip or dorsal dermis. Epithelial differentiation was analyzed using immunohistology with corneal monospecific monoclonal antibody AK12 (anti-keratin K12). Recombinants involving 12-day embryo undifferentiated corneal ectoderm formed a typical epidermis with hair follicles after 10 days of culture on the chick chorioallantoic membrane. Central corneal epithelium from 23- to 24-day embryos and newborn, which express suprabasally both K3 and K12 keratins and basally the K12 keratin alone, when grown in association with trichogenic dermis first failed to produce K12 in its new forming basal layer and then stratified after 11 days of culture above a differentiating epidermis with hair buds. When the culture period was increased up to 21 days by grafting under the kidney capsule from athymic mice, even the central corneal epithelium of 12-day-old off-spring gave rise to a complete epidermis with emerging hairs. The vibrissal- or pelage-type of hairs was in conformity with the regional origin of the mouse dermis. The species origin of the epithelia...Continue Reading

References

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Citations

Jan 11, 2007·Cell Research·Wei LiScheffer C G Tseng
Apr 17, 1999·Experimental Dermatology·G CotsarelisJ Bickenbach
Jul 11, 2006·Annual Review of Cell and Developmental Biology·Celeste M Nelson, Mina J Bissell
May 12, 2011·Biomicrofluidics·Declan RyanHongkai Wu
Nov 23, 2000·Proceedings of the National Academy of Sciences of the United States of America·R M Lavker, T T Sun
Jan 22, 2013·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elodie CollombDanielle Dhouailly
Aug 19, 2014·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Danielle DhouaillyFrederic Michon
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Aug 16, 2005·Current Opinion in Biotechnology·Kurt S Stenn, George Cotsarelis
Jul 3, 2013·International Journal of Molecular Sciences·Michael CangkramaCharbel Darido
Jul 13, 2007·Stem Cell Reviews·Kristin M Braun, David M Prowse
Sep 4, 2020·Experimental Eye Research·Winston W-Y Kao
Feb 18, 2021·Signal Transduction and Targeted Therapy·Shuaifei JiXiaobing Fu
Oct 1, 1996·Dermatologic Clinics·C A Jahoda, A J Reynolds

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