Transducing Complex Biomolecular Interactions by Temperature-Output Artificial DNA Signaling Networks.

Journal of the American Chemical Society
Lei HeWeihong Tan

Abstract

The requirement of special expensive instruments for quantitative information readout has significantly restricted sustainable development, from ideation to execution, of advanced artificial networks. Here we present a step toward a paradigm of evolutionary signaling networks that enable translating complex signaling information into easy-to-read temperature output. Combining DNA molecular engineering with basic optical mechanisms, a DNA/Hemin complex-derived versatile temperature-output transducer is established, which can be coupled with other functional modules to fabricate diverse portable DNA signaling networks by dynamic programming of DNA chemical reactions. Its versatility is successfully demonstrated by constructing self-amplified and logic-circuit-based DNA signaling networks to monitor trace and multibit nucleic acid interactions using a thermometer. This affordable yet powerful DNA signaling network design may portend an era of point-of-care signaling network methodology.

References

Dec 6, 2001·Nature Reviews. Molecular Cell Biology·J J TysonB Novak
Jan 22, 2004·Nature Reviews. Genetics·Albert-László Barabási, Zoltán N Oltvai
Sep 4, 2008·Journal of the American Chemical Society·Minggang DengXiang Zhou
Dec 13, 2012·Chemical Reviews·Hongquan ZhangX Chris Le
Dec 26, 2013·Journal of the American Chemical Society·Mingxu YouWeihong Tan
Apr 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Seyed-Fakhreddin TorabiYi Lu
Mar 10, 2016·Chemical Society Reviews·Hong-Min MengXiao-Bing Zhang
Mar 7, 2017·Nature Communications·Hanyong PengX Chris Le
Jul 18, 2017·Journal of the American Chemical Society·Xiangmeng QuChunhai Fan
Jul 25, 2017·Nature Nanotechnology·Gourab ChatterjeeGeorg Seelig
Jul 27, 2017·Nature·Alexander A GreenPeng Yin
Dec 1, 2017·Analytical Chemistry·Hanyong PengHongquan Zhang
May 11, 2018·Journal of the American Chemical Society·Yifan LyuWeihong Tan
Jul 3, 2018·Journal of the American Chemical Society·Liang YueItamar Willner
Nov 7, 2018·Nature Materials·Jie ChaoChunhai Fan
Apr 4, 2019·Journal of the American Chemical Society·Hui LiuWeihong Tan

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