PMID: 6108075Nov 1, 1980Paper

Transduction mechanisms in carotid body: glomus cells, putative neurotransmitters, and nerve endings

The American Journal of Physiology
C Eyzaguirre, S J Fidone

Abstract

Carotid body chemoreceptors are activated by low PO2, high PCO2, acidity, increased temperature, and tonicity. These receptors are important in homeostasis and mediate their reflex effects on the CNS through sensory discharges of the carotid (sinus) nerve. The receptor complex is formed by glomus (type I) cells and carotid nerve endings, which, morphologically, appear to form a sensory synapse. The junction between glomus cells and nerve endings is enveloped by processes of sustentacular (type II) cells. The mechanisms of chemoreceptor transduction are complex; there is no agreement about the identity of the primary receptor element (glomus cell or nerve terminal) or what mechanisms are responsible for the onset of the sensory discharge in the carotid nerve. There is increasing evidence that integrity of the glomus cell is essential for normal transduction and that the receptor synapse described by morphologists may be functionally active. There is no conclusive evidence, however, that the glomus cell is the primary site of sensory transduction. Stimuli act on the glomus cell to release "transmitter" and/or "modulator" substances; but it is unknown if the released chemicals are directly responsible for the accompanying change i...Continue Reading

References

Jan 1, 1978·Neuroscience·E MillsG Breese
Aug 31, 1979·Brain Research·C GonzalezS J Fidone
Sep 1, 1979·Journal of Neurochemistry·C GonzalezS Fidone
Jun 1, 1978·The Journal of General Physiology·C C HuntY Fukami
Apr 24, 1975·Nature·M P Osborne, P J Butlar
Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·E J FurshpanD D Potter
Jan 1, 1975·The Journal of Physiology·P Zapata
Apr 1, 1978·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·D S McQueen
Jan 1, 1979·International Review of Cytology·A Verna
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S T CarbonettoK J Muller
May 1, 1979·Journal of Neurophysiology·R GallegoL Monti-Bloch
May 5, 1979·Brain Research·Y Hayashida, C Eyzaguirre
Apr 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·J W BellvilleD M Wiberg
May 1, 1979·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·Y HondaJ W Severinghaus
Jan 1, 1978·The Journal of Physiology·F Llados, P Zapata
Jun 1, 1978·British Journal of Pharmacology·M J AminoffE H Vidruk
Jun 1, 1978·The Journal of Physiology·R J Docherty, D S McQueen
Jan 1, 1978·Neuroscience·E W KieneckerD Bingmann
Jan 1, 1977·Acta Anatomica·A Hess
Jun 1, 1976·The American Journal of Physiology·S R SampsonE H Vidruk
Nov 19, 1966·Nature·S R ChiocchioJ H Tramezzani
Jan 1, 1967·Histochemie. Histochemistry. Histochimie·A E BeckerA E Meijer
Apr 1, 1968·The Journal of Physiology·C Eyzaguirre, P Zapata

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Citations

Nov 17, 2010·The Journal of Physiology·Yanfeng DingHarold D Schultz
Sep 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T D Boyer, D A Vessey
Feb 1, 1989·Acta Physiologica Scandinavica·A DahlqvistS Hellström
Mar 12, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·François M Abboud
Jan 28, 2020·American Journal of Physiology. Renal Physiology·Marcelo D Carattino, Nicolas Montalbetti
Jan 1, 1982·Cell and Tissue Research·K Ishii, T Kusakabe
Jan 1, 1987·Annals of the New York Academy of Sciences·H Acker
Sep 8, 2005·Journal of Intensive Care Medicine·Pamela J Fall, Harold M Szerlip
Sep 17, 1998·The New England Journal of Medicine·V L Hood, R L Tannen
Dec 31, 2002·The Annals of Pharmacotherapy·Jamshed K KhanThomas R Hornick
Jan 1, 1995·Progress in Biophysics and Molecular Biology·W Hamann

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