Transduction signals induced in rat brain cortex astrocytes by the HIV-1 gp120 glycoprotein

FEBS Letters
F CodazziJ Meldolesi

Abstract

Cultures of rat brain cortex astrocytes were exposed to 10(-10)-10(-9)M of the HIV-1 envelope glycoprotein, gp120. No specific binding was revealed by the iodinated protein, suggesting expression of only a few sites onto the cells. In contrast, two transduction signals were rapidly induced by gp120: increased tyrosine phosphorylation of a approximately 56 kDa protein and increased [Ca2+]i. This latter effect, present in 1/3 of the investigated astrocytes, consisted in: discrete or biphasic peaks; slowly rising plateaus; and various types of oscillations. Moreover, in apparently unresponsive cells [Ca2+]i rose slowly (45 min) to double the resting levels. Rat brain cortex astrocytes thus appear highly sensitive to gp120. The induced array of signals might contribute to neurotoxicity during HIV infection.

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Citations

Nov 14, 2000·Biological Psychiatry·S M Brooke, R M Sapolsky
Feb 7, 2001·Annual Review of Psychology·L R Watkins, S F Maier
May 26, 2005·Brain Research. Brain Research Reviews·Lyle W Ostrow, Frederick Sachs
Jan 1, 1997·Neurobiology of Disease·M P Cuajungco, G J Lees
Feb 11, 1998·Physiological Reviews·A VerkhratskyH Kettenmann

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