PMID: 602683Nov 28, 1977Paper

Transendothelial vesicular transport of protein in brain edema induced by ultraviolet irradiation

Acta Neuropathologica
S SasakiJ Cervós-Navarro

Abstract

Focal vasogenic brain edema was induced by ultraviolet irradiation of the exposed cerebral cortex of 16 cats. In 5 animals horseradish peroxidase was intravenously injected at times varying from 30 min to 24 h following irradiation and allowed to circulate for 45 min. Fixation was carried out by perfusion and immersion with glutaraldehyde. The tissue, part of it incubated for peroxidatic activity, was treated for electron microscopy. The UV-irradiation leads to a shallow coagulation of the superficial cortex from which a wide zone of edematous tissue spreads to the deep white matter within 24 h. Arterioles, capillaries and venules of this zone show enhanced pinocytotic activity and a concurrent rise in permeability for horseradish peroxidase which is found in micro- and macropinocytotic vesicles, in tubular vesicle-like structures, in endothelial wall invaginations and apparently not membrane-bound. These changes are most pronounced in venules which after 48 h allow penetration of reaction product though the base membrane into the surrounding neuropil. There is no evidence for the penetration of tight junctions which appear intact.

References

Oct 1, 1971·Journal of Neuropathology and Experimental Neurology·R N BakerS P Frommes
Jan 1, 1967·Journal of Neuropathology and Experimental Neurology·I Klatzo
Mar 1, 1969·The Journal of Cell Biology·M W Brightman, T S Reese
Mar 1, 1969·Archives of Neurology·A HiranoH M Zimmerman
Oct 1, 1958·Journal of Neuropathology and Experimental Neurology·I KLATZOE J LASKOWSKI
Oct 1, 1962·Journal of Neuropathology and Experimental Neurology·R A CLASENA J RAIMONDI
Mar 16, 1964·Archiv für Psychiatrie und Nervenkrankheiten·J CERVOS NAVARRO

❮ Previous
Next ❯

Citations

Nov 1, 1979·Stroke; a Journal of Cerebral Circulation·M D O'Brien
Apr 1, 1992·Neuropathology and Applied Neurobiology·J V LafuenteJ Cervos-Navarro
Jul 1, 1980·Neuropathology and Applied Neurobiology·E Westergaard
Jun 30, 1978·Acta Neuropathologica·R FersztJ Sperner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.