PMID: 1206853Dec 11, 1975Paper

Transepithelial potential difference profile of the distal tubule of the rat kidney

Kidney International
L J BarrattD W Seldin

Abstract

In a recent micropuncture study electrodes with relatively large tips (3 to 5 mu O.D.) and, hence, low tip resistances were used to measure the transepithelial potential difference (PD) across the proximal tubule of the rat kidney. The present study reexamines the PD of the distal tubule of the rat kidney using such electrodes. In contrast to previous studies where a negative PD has been uniformly found in the distal tubule, the transtubular PD was found to be positively oriented (+3.7 mv) when particular efforts were made to puncture the earliest accessible segments. In accord with previous observations, the PD of the late segment was consistently negative (mean, -19.6 mv). Morphologic examination of the epithelium at the site of puncture suggests that in the very early distal tubule where positive potentials are recorded, the epithelium is characteristic of the distal convoluted tubule. By contrast, in the latter part of the distal tubule, where negative potentials are recorded, the epithelium displays the morphologic characteristics of the cortical collecting duct. The results of these studies suggest that the net transport properties of the distal tubule, that is the region of the nephron beginning just beyond the macula de...Continue Reading

References

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Citations

Jan 23, 1979·Journal of Mathematical Biology·R Kainer
Sep 1, 1989·Pflügers Archiv : European journal of physiology·T ShimizuM Imai
Nov 1, 1982·Pflügers Archiv : European journal of physiology·J Teulon, T Anagnostopoulos
Feb 24, 1976·Pflügers Archiv : European journal of physiology·L J Barratt
Jan 1, 1979·Comparative Biochemistry and Physiology. C: Comparative Pharmacology·S J LeBrie, B D Boelcskevy
May 2, 2012·The Journal of Physiology·A K M Shamsuddin, P M Quinton
Jun 1, 1977·Kidney International·F S Wright
Aug 1, 1986·Kidney International·G A Quamme, J H Dirks
Nov 1, 1986·Kidney International·W J WelchT A Kotchen
May 1, 1989·Kidney International·G G Allen, L J Barratt
Jun 1, 1985·Kidney International·G G Allen, L J Barratt
Jan 1, 1981·Australian and New Zealand Journal of Medicine·L J Barratt
Dec 4, 2019·Physiological Reviews·Ewout J HoornRobert A Fenton
Jun 11, 1999·The American Journal of Physiology·H Chang, T Fujita
Jan 5, 2000·Physiological Reviews·R F Reilly, D H Ellison
Jun 1, 1977·Kidney International·A D Macknight

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