Transepithelial transport across Caco-2 cell monolayers of antihypertensive egg-derived peptides. PepT1-mediated flux of Tyr-Pro-Ile

Molecular Nutrition & Food Research
Marta MiguelRosina López-Fandiño

Abstract

This paper examines the in vitro transepithelial transport of antihypertensive peptides derived from egg proteins using Caco-2 cell monolayers. Ovokinin (FRADHPFL) was absorbed intact through the Caco-2 cell epithelium, although it was also susceptible to the action of brush-border aminopeptidases that yielded shorter fragments prior to their transport. The tripeptide YPI was resistant to cellular peptidases and transported through the monolayer, what suggests that the reduction in systemic blood pressure caused by this peptide may be mediated by effects at tissue level. Its pathway for transepithelial absorption was examined using inhibitors of the different mechanisms for oligopeptide transport in the intestinal tract. The main route involved in the transepithelial flux of YPI is probably the peptide H(+)-coupled transporter PepT1. These results highlight the potential of antihypertensive peptides to be used in the formulation of functional foods.

References

Aug 1, 1990·The Biochemical Journal·J DyerS P Shirazi-Beechey
Nov 24, 1995·The Journal of Biological Chemistry·S H HansenJ E Casanova
Mar 1, 1995·British Journal of Pharmacology·D T ThwaitesN L Simmons
Jan 1, 1994·Annual Review of Pharmacology and Toxicology·G L Amidon, H J Lee
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·J R PappenheimerJ E Maggio
Jul 23, 1993·Regulatory Peptides·P K RangachariT Prior
Jul 30, 1999·Biochemical and Biophysical Research Communications·T FujitaF H Leibach
Aug 9, 2001·Nestlé Nutrition Workshop Series. Clinical & Performance Programme·G K Grimble
Apr 5, 2002·Journal of Peptide Science : an Official Publication of the European Peptide Society·V VermeirssenW Verstraete
May 10, 2002·Bioscience, Biotechnology, and Biochemistry·Makoto SatakeMakoto Shimizu
Aug 7, 2002·Bioscience, Biotechnology, and Biochemistry·Yuko YamadaMasaaki Yoshikawa
Oct 31, 2002·Pharmacology & Toxicology·Birger BrodinSven Frøkjaer
Jun 5, 2004·Regulatory Peptides·Phouangmala ScruggsNae J Dun
Sep 2, 2004·Pflügers Archiv : European journal of physiology·Megumi IrieKen-Ichi Inui
Oct 8, 2004·The British Journal of Nutrition·Vanessa VermeirssenWilly Verstraete
Nov 10, 2005·The British Journal of Nutrition·Marta MiguelAmaya Aleixandre
Dec 20, 2005·International Journal of Food Sciences and Nutrition·Vanessa VermeirssenWilly Verstraete
May 17, 2006·The Journal of Nutrition·Marta Miguel, Amaya Aleixandre
Jun 17, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E BernasconiB Corthésy
Jan 16, 2007·Regulatory Peptides·Marta MiguelMercedes Salaices
Jun 8, 2007·Journal of Peptide Science : an Official Publication of the European Peptide Society·Misako Aito-InoueYoshinori Mine

❮ Previous
Next ❯

Citations

Mar 22, 2013·The Journal of Dairy Research·Francisco Javier Espejo-CarpioAntonio Guadix
Feb 18, 2016·International Journal of Food Sciences and Nutrition·Long DingJingbo Liu
Sep 4, 2015·Journal of Agricultural and Food Chemistry·Long DingJingbo Liu
Jul 31, 2012·Biochimica Et Biophysica Acta·Jennifer Kovacs-NolanYoshinori Mine
Apr 11, 2017·Journal of Agricultural and Food Chemistry·Mengmeng Feng, Mirko Betti
Mar 24, 2017·Nutrients·Ceren Daskaya-DikmenBeraat Ozcelik
Jun 14, 2017·Critical Reviews in Food Science and Nutrition·Ya-Fei LiuPat Silcock
May 13, 2017·Journal of Biomaterials Applications·Chenhui ZhuYuanyuan Yu
Jan 19, 2010·Pharmaceuticals·Pauliina Jäkälä, Heikki Vapaatalo
Sep 26, 2017·Food & Function·Charlotte GrootaertJohn Van Camp
Nov 16, 2017·Food & Function·Weilin Shen, Toshiro Matsui
Apr 17, 2010·Molecular Nutrition & Food Research·Daniela RegazzoRachel Boutrou
Sep 18, 2020·Molecular Nutrition & Food Research·Shaun J SharkeyFinbarr P M O'Harte
Aug 8, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Huijuan ZhangJing Wang
Feb 3, 2021·Comprehensive Reviews in Food Science and Food Safety·Lu XuePangzhen Zhang
Jul 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Shanshan LiJianping Wu
Dec 2, 2017·Bioscience, Biotechnology, and Biochemistry·Hideo SatsuMakoto Shimizu
Nov 4, 2017·Journal of Agricultural and Food Chemistry·Gilda AielloAnna Arnoldi
Apr 11, 2019·Journal of Agricultural and Food Chemistry·Liying WangJingbo Liu
Jan 10, 2013·Journal of Agricultural and Food Chemistry·Satyanarayana Bejjani, Jianping Wu
Aug 8, 2017·Journal of Agricultural and Food Chemistry·Qingbiao XuJianping Wu
Oct 29, 2021·Critical Reviews in Food Science and Nutrition·Hija Athman KatimbaCuilin Cheng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.