Transepithelial transport of ferulic acid by monocarboxylic acid transporter in Caco-2 cell monolayers

Bioscience, Biotechnology, and Biochemistry
Yutaka Konishi, Makoto Shimizu

Abstract

Our previous study (Biosci. Biotechnol. Biochem., 66, 2449-2457 (2002)), suggested that ferulic acid was transported via a monocarboxylic acid transporter (MCT). Transepithelial transport of ferulic acid was examined in this study by directly measuring the rate of its transport across Caco-2 cell monolayers. Ferulic acid transport was dependent on pH, and in a vectorical way in the apical-basolateral direction. The permeation of ferulic acid was concentration-dependent and saturable; the Michaelis constant was 16.2 mM and the maximum velocity was 220.4 nmol min-1 (mg protein)-1. Various substrates for MCTs, such as benzoic acid and acetic acid, strongly inhibited the permeation of ferulic acid, demonstrating that ferulic acid is obviously transported by MCT. Antioxidative phenolic acid compounds from dietary sources like ferulic acid would be recognized and transported by MCT by intestinal absorption.

References

Oct 1, 1992·Free Radical Biology & Medicine·E Graf
Sep 21, 1990·Biochimica Et Biophysica Acta·I J Hidalgo, R T Borchardt
Sep 1, 1990·Pharmaceutical Research·A R HilgersP S Burton
Jul 20, 1990·Biochimica Et Biophysica Acta·I J Hidalgo, R T Borchardt
Nov 1, 1981·Journal of Pharmacobio-dynamics·K YamaokaT Uno
Jan 8, 1999·Biochemical and Biophysical Research Communications·L C Bourne, C Rice-Evans
Mar 24, 2000·Free Radical Research·L BourneC Rice-Evans
Aug 5, 2000·The Journal of Nutrition·A Scalbert, G Williamson
Feb 1, 1994·Plant Physiology·K. IiyamaB. A. Stone

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Citations

Dec 4, 2003·Bioscience, Biotechnology, and Biochemistry·Yutaka KonishiMakoto Shimizu
Oct 31, 2003·Bioscience, Biotechnology, and Biochemistry·Yutaka Konishi
Mar 24, 2005·Bioscience, Biotechnology, and Biochemistry·Yutaka Konishi, Shoko Kobayashi
Sep 2, 2014·Biological & Pharmaceutical Bulletin·Osamu KimuraTetsuya Endo
May 16, 2014·Nutrition Reviews·Torsten Bohn
Aug 24, 2006·Bioscience, Biotechnology, and Biochemistry·Hirohito WatanabeYutaka Konishi
Feb 9, 2010·Bioscience, Biotechnology, and Biochemistry·Makoto Shimizu
Jul 26, 2011·The Proceedings of the Nutrition Society·Wendy Russell, Garry Duthie
Aug 12, 2015·International Journal of Molecular Sciences·Isabel Borrás-LinaresAntonio Segura-Carretero
Feb 11, 2009·Molecular Nutrition & Food Research·Wendy R RussellGarry G Duthie
Aug 23, 2008·The Journal of Pharmacy and Pharmacology·Masaaki KadowakiKoji Furuno
Aug 2, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Chenlin ShenJun Li
Mar 7, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Chung-Ping YuYu-Chi Hou
Jan 15, 2008·Biochemical and Biophysical Research Communications·Shoko Kobayashi, Yutaka Konishi
Dec 26, 2012·Food Chemistry·Hoang Lan PhuongToshiro Matsui
Jul 12, 2005·Biochimica Et Biophysica Acta·Yutaka Konishi
Nov 21, 2007·Biochimica Et Biophysica Acta·Shoko KobayashiYutaka Konishi
Aug 19, 2016·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ruonan ChenJun Li
Apr 4, 2013·The American Journal of Chinese Medicine·Hsueh-Jung LiuYu-Chi Hou
Jan 4, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ke LiuXinjie Guo
Jan 25, 2006·Critical Reviews in Food Science and Nutrition·Sailendra N NichenametlaJerry H Exon
Jan 13, 2018·Journal of the Science of Food and Agriculture·Mariem AchourRaquel Mateos
Sep 29, 2005·Molecular Nutrition & Food Research·Franck TourniaireMarie-Josèphe Amiot
Sep 1, 2011·Food & Function·Garry G Duthie, Adrian D Wood
Oct 24, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Laure PoquetGary Williamson
Dec 13, 2017·Journal of Biosciences·Gavirangappa HithamaniKrishnapura Srinivasan
May 17, 2018·Applied Microbiology and Biotechnology·Florian MeyerAlexander Steinbüchel
Jan 1, 2014·Comprehensive Reviews in Food Science and Food Safety·Neda Nićiforović, Helena Abramovič
Apr 30, 2008·Journal of Agricultural and Food Chemistry·Lisbeth A Pacheco-PalenciaSusanne Mertens-Talcott
Jul 17, 2021·Frontiers in Nutrition·Maria Carolina Rodríguez-DazaDenis Roy
Apr 2, 2009·Journal of Agricultural and Food Chemistry·Mirella NardiniCristina Scaccini
Aug 31, 2012·Journal of Agricultural and Food Chemistry·Hesham R El-SeediRob Verpoorte
Aug 15, 2008·Food Chemistry·Zhaohui Zhao, Mohammed H Moghadasian

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