PMID: 9426698Jan 14, 1998Paper

Transfection of TAP 1 gene restores HLA class I expression in human small-cell lung carcinoma

International Journal of Cancer. Journal International Du Cancer
D P SingalD Bienzle

Abstract

HLA class I antigens of the human major histocompatibility complex (MHC) play an important role in immune response. Consistent with their role in immune surveillance, these antigens are expressed on most cell types. However, a marked deficiency or lack of expression of these antigens has been observed in a variety of human neoplasms. We have shown that a number of class I-deficient human tumor cell lines, including small-cell lung carcinoma, lacked products of MHC-encoded TAP1 and LMP2 genes. Since a direct evidence for the role of these genes in class I expression in tumor cells is not available, in the present study we transfected class I-deficient human small-cell lung carcinoma cells with cDNAs corresponding to TAP1 gene and to LMP2 gene. Following transfection, tumor cells expressed products of the respective transfected gene. Cell-surface expression of class I molecules was, however, observed in cells transfected with TAP1, but not in tumor cells transfected with LMP2 gene. Our results provide conclusive evidence for a role of TAP1 gene in class I expression and suggest that transfection of TAP genes may be useful to upregulate class I expression in tumor cells. This strategy for restoration of class I expression by trans...Continue Reading

References

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Jan 27, 1995·The Journal of Biological Chemistry·D P SingalS A Quadri
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Citations

Mar 17, 1999·International Journal of Cancer. Journal International Du Cancer·M KallfelzB Seliger
Feb 6, 2007·International Journal of Cancer. Journal International Du Cancer·Qian-Jin ZhangWilfred A Jefferies
Feb 13, 2003·The Journal of Biological Chemistry·Tianyu YangPan Zheng
Nov 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Craig I FineJane A McCutcheon
Jul 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Robert L FerrisSoldano Ferrone
Mar 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuanmei LouWilfred A Jefferies

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