PMID: 6107585Nov 1, 1980Paper

Transfer factor in treatment of multiple sclerosis

Lancet
A BastenC M Van Der Brink

Abstract

A 2-year prospective double-blind trial of the treatment of multiple sclerosis patients with the leucocyte extract, transfer factor (TF), obtained from leucocytes of relatives living with the patient, was conducted. 60 patients with definite MS, of whom 58 completed the trial, were divided into two equal groups, one of which received TF and the other placebo. The groups were evenly balanced with respect to sex ratios, disability, duration of disease, ratio of moderate to severe cases, and HLA phenotype. Neurological, electrophysiological, and immunological assessments were done at the start of the trial and every 6 months thereafter. The results indicated that (1) TF retarded but did not reverse progression of the disease; (2) a significant difference between treatment and placebo groups was not apparent with 18 months after the start of the trial; and (3) treatment was effective only in those patients with mild to moderate disease activity.

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Citations

Jan 1, 1983·Journal of Neurology·R A Hughes
Jun 1, 1989·Journal of Neuroimmunology·W D LymanM B Bornstein
Nov 28, 2007·Immunology and Cell Biology·Antony Basten
Jun 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·J C WalshJ G McLeod
Feb 1, 1981·Immunology Today·R A Hughes
Jun 1, 1983·Immunology Today·G B Wilson, H Hugh Fudenberg
Jan 1, 1982·Annals of the New York Academy of Sciences·E Roberts
Jan 1, 1984·Annals of the New York Academy of Sciences·D H Silberberg
Aug 1, 1982·Australian and New Zealand Journal of Medicine·J G McLeod
Aug 1, 1983·Acta Neurologica Scandinavica·W I McDonald
Feb 1, 1982·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·K G WarrenT A McPherson
Jan 1, 1994·Journal of Clinical Apheresis·R D MedenicaT Huschart
Oct 1, 1986·Acta Neurologica Scandinavica·C Caltagirone, A Carlesimo
Aug 1, 1984·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J H NoseworthyG C Ebers
Apr 14, 1984·The Medical Journal of Australia·P A Gatenby, A Basten

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