PMID: 8594901Dec 1, 1995Paper

Transfer function analysis of vagal control of heart rate during synchronized vagal stimulation

The American Journal of Physiology
A MokraneR Nadeau

Abstract

Synchronized electrical stimulation was used to study the heart rate (HR) response to fluctuations in parasympathetic input to the sinus node in anesthetized dogs. This was obtained by varying the time interval (interpulse interval) between stimulatory vagal pulses. Spectral methods were used to estimate transfer functions between the excitatory signal and the resulting HR response for different intensities of vagal stimulation. The intensity of vagal stimulation was proportional to the number of pulses delivered in each cardiac cycle. From the estimated transfer functions, and based on a mathematical model of the time course of ACh concentration at the sinus node, filter models were derived by using a system identification approach. HR response was characterized by a combination of two different filter behaviors: a low-pass filter behavior of mean cut-off frequency of 0.065 Hz and an all-pass filter behavior. The magnitude of the low-pass filter gain decreased with increasing intensity of vagal stimulation. The magnitude of the all-pass filter gain increased and then decreased with increasing intensity of vagal stimulation. The all-pass filter characteristics of HR response during synchronized stimulation of the vagus nerves a...Continue Reading

Citations

Jun 23, 2011·PloS One·Fausto LucenaNoboru Ohnishi
Nov 2, 2014·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Elhacene MateneVincent Jacquemet
Dec 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·Simon C Malpas
Jul 24, 2001·Medical & Biological Engineering & Computing·G D Pinna, R Maestri

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