PMID: 7082315Jan 15, 1982Paper

Transfer of 1-pyrroline-5-carboxylate as oxidizing potential from hepatocytes to erythrocytes

The Biochemical Journal
C H HagedornJ M Phang

Abstract

The interconversions of proline and 1-pyrroline-5-carboxylate form an intercellular cycle that is the basis of a metabolic interaction between hepatocytes and erythrocytes. The cycle transfers oxidizing potential from hepatocytes to erythrocytes, which stimulates pentose phosphate pathway in erythrocytes. This interaction depends on the differential metabolism of proline and 1-pyrroline-5-carboxylate in erythrocytes and hepatocytes and consists of the following: in hepatocytes proline oxidase converts proline into 1-pyrroline-5-carboxylate, which is released into the medium and taken up by erythrocytes; erythrocyte 1-pyrroline-5-carboxylate reductase converts 1-pyrroline-5-carboxylate into proline and concomitantly generates NADP+; the generated oxidizing potential drives glucose metabolism through the pentose phosphate pathway in erythrocytes; finally, erythrocytes release proline into the medium, enabling it to re-enter hepatocytes and repeat the cycle. The increased activity of the pentose phosphate pathway in erythrocytes may enhance the production of 5-phosphoribosyl pyrophosphate, a necessary moiety for the processing of purines.

Citations

Nov 12, 2015·International Journal of Molecular Sciences·Sofia CarettoVincenzo Lattanzio
Aug 9, 2011·The Veterinary Journal·V DavidsE H Harley
Aug 1, 1991·In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association·B A Semon, J M Phang
Feb 21, 2013·Epigenetics : Official Journal of the DNA Methylation Society·James M PhangChad Hancock

Related Concepts

delta-1-pyrroline-5-carboxylate, 14C-labeled, (+-)-isomer
Erythrocytes
Liver
Oxidation-Reduction
Pentosephosphates
Proline
Proline Dehydrogenase
Pyrroles
August Rats

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