PMID: 2111275Apr 1, 1990Paper

Transfer of beta-lactamase plasmids by conjugation in Neisseria gonorrhoeae

Genitourinary Medicine
C A IsonN Woodford

Abstract

Conjugation experiments in vitro have been used in an attempt to explain certain epidemiological phenomena seen amongst penicillinase producing Neisseria gonorrhoeae (PPNG) isolated at St Mary's Hospital, London. These include changes in plasmid profiles, a lack of beta-lactamase encoding plasmids in PAOU-requiring strains and a difference in the serological classification of strains of PPNG and non-PPNG isolated from the same clinic. It was shown that acquisition of the conjugative plasmid by beta-lactamase producing transconjugants does vary, but is not related to the auxotype/serovar (A/S) class of, or type of beta-lactamase plasmid carried by the donor. It was not possible to transfer either the 3.2MDa or 4.4MDa plasmids to PAOU-requiring strains of N gonorrhoeae. The conjugation frequency from a single donor to different recipients was shown to be variable, but was not influenced by the serovar of the recipients. It was shown that the transfer and acceptance of beta-lactamase encoding plasmids is variable but it was not possible to identify the factors responsible.

References

Sep 25, 1976·Lancet·W A AshfordV G Hemming
Dec 25, 1976·Lancet·A PercivalE H Annels
Oct 1, 1979·Journal of General Microbiology·M RobertsS Falkow
Nov 24, 1979·Nucleic Acids Research·H C Birnboim, J Doly
Mar 11, 1977·Science·B I EisensteinP F Sparling
Apr 14, 1977·Nature·M Roberts, S Falkow
Apr 1, 1989·The Journal of Antimicrobial Chemotherapy·M Brett
Dec 1, 1989·Journal of Medical Microbiology·C A Ison, C S Easmon
Feb 1, 1985·The Journal of Antimicrobial Chemotherapy·J D Van EmbdenB Van Klingeren
Jun 1, 1986·Antimicrobial Agents and Chemotherapy·A GoubyM Ramuz
Oct 1, 1986·Genitourinary Medicine·C A IsonC S Easmon
Apr 1, 1972·Antimicrobial Agents and Chemotherapy·C H O'CallaghanA H Shingler
Aug 1, 1983·Journal of Medical Microbiology·C G Copley, S I Egglestone
Aug 1, 1981·Infection and Immunity·J R Dillon, M Pauzé

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Citations

May 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·A GuyotD Dore
Aug 1, 1991·Genitourinary Medicine·C A Ison, C S Easmon

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