Transfer of copper between bis(thiosemicarbazone) ligands and intracellular copper-binding proteins. insights into mechanisms of copper uptake and hypoxia selectivity

Inorganic Chemistry
Zhiguang XiaoAnthony G Wedd

Abstract

Bis(thiosemicarbazonato) complexes Cu(II)(Btsc) have attracted interest as promising metallodrugs and, in particular, as copper radiopharmaceuticals. Prototypes Cu(Atsm) and Cu(Gtsm) are membrane-permeable, but their metabolisms in cells are distinctly different: copper that is delivered by Cu(Gtsm) is trapped nonselectively in all cells, whereas copper that is delivered by Cu(Atsm) is retained selectively in hypoxic cells but is "washed out" readily in normal cells. We have studied copper-transfer reactions of these two complexes under various conditions, aiming to model their cellular chemistry. In Me2SO, both complexes exhibited reversible one-electron-reduction processes with Cu(Atsm) being more difficult to reduce than Cu(Gtsm) (E(1/2)'=-0.60 and -0.44 V, respectively, vs AgCl/Ag). Upon introduction of an aqueous buffer into Me2SO, the electrochemical reduction remained chemically reversible for Cu(Atsm) but became irreversible for Cu(Gtsm). However, the estimated difference in their reduction potentials did not change. Chromophoric ligand anions bicinchonate (Bca) and bathocuproine disulfonate (Bcs) were used as Cu(I) indicators to trace the destinations of copper in the reactions and to mimic cellular Cu(I)-binding compo...Continue Reading

References

Jul 1, 1979·Journal of Inorganic Biochemistry·R OsterbergD Persson
Oct 1, 1991·The American Journal of Clinical Nutrition·K R DhariwalM Levine
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B FreiB N Ames
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Nov 1, 1996·Nuclear Medicine and Biology·P J BlowerJ Zweit
Nov 5, 1997·Science·R A PufahlT V O'Halloran
Jul 8, 1999·The Journal of Nutrition·M M PeñaD J Thiele
Jul 30, 1999·Nature Structural Biology·A L LambA C Rosenzweig
Jul 27, 2001·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Z XiaoA G Wedd
Mar 22, 2002·Journal of Medicinal Chemistry·Richard I MaurerGregory E D Mullen
Apr 6, 2002·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jason L J DearlingPhilip J Blower
Feb 28, 2004·The Journal of Nutrition·Guoyao WuNancy D Turner
Mar 5, 2004·Journal of Medicinal Chemistry·C Andrew BoswellCarolyn J Anderson
Apr 29, 2004·The Journal of Nutrition·Joseph R Prohaska, Anna A Gybina
Dec 17, 2005·Physics in Medicine and Biology·T C Rust, D J Kadrmas
Jan 27, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Jason P HollandJonathan R Dilworth
Dec 21, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Andrew R CowleySteven J Ratcliffe
Nov 10, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Amy L Vāvere, Jason S Lewis

❮ Previous
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Citations

Jul 4, 2012·Accounts of Chemical Research·Peter J Crouch, Kevin J Barnham
Nov 26, 2009·Journal of the American Chemical Society·Zhen MaDavid P Giedroc
Jan 17, 2013·Journal of Medicinal Chemistry·Duraippandi PalanimuthuAshoka G Samuelson
Jan 10, 2012·Chemical Communications : Chem Comm·Gojko BuncicPaul S Donnelly
Jan 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Peter J CrouchKevin J Barnham
Dec 17, 2011·Proceedings of the National Academy of Sciences of the United States of America·Paul S DonnellyPeter J Crouch
Jun 10, 2011·PLoS Genetics·Nuria Gómez-SantosJosé Muñoz-Dorado
Oct 24, 2013·AJR. American Journal of Roentgenology·Tian ZhangGordana Vlahovic
Jul 6, 2014·Food Chemistry·Melanie J CekoHugh H Harris
Oct 12, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Laura BicaPaul S Donnelly
Sep 23, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·SinChun LimPaul S Donnelly
May 4, 2010·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Jeffrey T RubinoKatherine J Franz
Mar 9, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Disha DayalAshoka G Samuelson
Oct 30, 2012·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Catherine LambertMilena Salerno
Dec 2, 2008·Journal of Cellular and Molecular Medicine·Yif'at BiranPaul A Adlard
Nov 12, 2013·British Journal of Pharmacology·A GrubmanJ R Liddell
Feb 24, 2015·Immunological Reviews·Olivier NeyrollesMichael Niederweis
Aug 27, 2015·Nature·Nicolas VitaChristopher Dennison
Feb 20, 2014·The Biochemical Journal·Katie L I M BlundellJonathan A R Worrall
Jan 1, 2015·Biochemical Pharmacology·Brian B HasinoffJack C Yalowich
Nov 26, 2009·Journal of Inorganic Biochemistry·Paul D BonnitchaJonathan R Dilworth
Nov 5, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Tatiana V PortoJonathan A R Worrall
Mar 24, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Marian E Helsel, Katherine J Franz
Sep 4, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Destinee K JohnsonNicholas E Grossoehme
Jun 19, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Amélie KochemFabrice Thomas
Jul 14, 2017·Dalton Transactions : an International Journal of Inorganic Chemistry·Mohamed WehbeMarcel B Bally
Apr 10, 2010·Natural Product Reports·Zhiguang Xiao, Anthony G Wedd
Jun 5, 2019·Proceedings of the National Academy of Sciences of the United States of America·M Thomas MorganChristoph J Fahrni
Jun 22, 2019·Scientific Reports·Stephan Schott-VerdugoGeorg Groth

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