PMID: 9166312May 1, 1997Paper

Transfer of erythropoietin across the placenta perfused in vitro

Obstetrics and Gynecology
K ReisenbergerP Husslein

Abstract

The purpose of this study was to investigate the placental passage of erythropoietin in a placental perfusion model ex vivo. In an open system 18 placentas were perfused on both the maternal and the fetal side. Erythropoietin and a reference substance were added to either the maternal or fetal perfusion medium. In the first series of experiments, radiolabeled erythropoietin was added to the perfusion medium in four different concentrations to help determine the transfer rate of erythropoietin. Based on the results of these experiments unlabeled erythropoietin was added to the perfusate in three different concentrations. Radiolabeled erythropoietin was used in addition to erythropoietin because measuring radioactivity in a gamma counter is less expensive than measuring by immunoassay. Accumulation of radioactivity in the venous portion of the fetal circuit was only 3.21% of the activity added to the maternal circuit. No evidence of transfer of erythropoietin to the contralateral compartment was noted, regardless of whether the test substance was added maternally or fetally. These results were independent of the concentration used. The reference compound antipyrine showed a mean transfer rate of 27.9%, which is in keeping with pr...Continue Reading

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Citations

Nov 22, 2011·Current Diabetes Reports·M GausterU Hiden
Feb 28, 2004·Journal of Pharmacological and Toxicological Methods·P Myllynen, K Vähäkangas
Jul 26, 2002·Pediatrics International : Official Journal of the Japan Pediatric Society·Fujio KakuyaKiminori Sasaki
Aug 14, 1998·Obstetrical & Gynecological Survey·M Vora, A Gruslin
Oct 29, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Janet Goshorn, Timothy D Youell
Jun 8, 2012·The Journal of Obstetrics and Gynaecology Research·Ozlem Gun EryilmazElif Gul Eyi
Jan 16, 2010·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Pauline L MartinPeter J Bugelski
Jun 2, 2007·Expert Opinion on Drug Metabolism & Toxicology·Päivi MyllynenKirsi Vähäkangas
Jan 8, 2004·American Journal of Obstetrics and Gynecology·Lowell E DavisRobert A Brace
Aug 28, 2016·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Luis Rodrigo Sanchez-GonzalezAlejandro Quiroga-Garza
Feb 27, 2018·Blood Purification·Jessica TangrenMichelle A Hladunewich
Aug 2, 2019·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Shannon PytelDiana Badoiu
Dec 3, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Imad ShamsAaron Avivi
Mar 20, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Elisabeth SölderPaul L Debbage

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