Transfer of esterified cholesterol from serum lipoproteins to the liver.

Biochimica Et Biophysica Acta
Z D Goodman, V S Lequire

Abstract

The fate of cholesteryl esters of the serum lipoproteins was studied in intact rats and in isolated perfused rat livers. The lipoproteins of fasting rat serum were labeled in vitro with [3H]cholesteryl oleate. Following intravenous injection, it was found that the majority of the radioactive ester was rapidly taken up by the liver where hydrolysis of the ester bond occurred. At 5 min, 58% of the injected material was recovered in the liver, 85% of which was still in the ester form, while at 30 min only 22% of the liver radioactivity was in cholesteryl esters. There was very little difference in the rate at which radioactivity was taken up from the different lipoprotein classes. Similar phenomena were observed in the perfused liver, but it was found that although the radioactive esters were being taken up, there was no change in the concentrations of free or esterified cholesterol in the perfusing medium, indicating that the lipoprotein cholesteryl ester was gaining access to the liver through an exchange of molecules. After uptake, cell fractionation experiments showed that the plasma membranes had the greatest relative amounts of radioactivity, suggesting that this is the site of exchange. Small amounts of radioactivity were r...Continue Reading

References

Oct 5, 1971·Biochimica Et Biophysica Acta·A Nilsson, D B Zilversmit
Dec 20, 1973·Biochimica Et Biophysica Acta·S Eisenberg, D Rachmilewitz
Nov 5, 1970·The New England Journal of Medicine·P Siekevitz
Sep 17, 1971·Biochemical and Biophysical Research Communications·R V HayR W Wissler
Mar 1, 1970·The Journal of Clinical Investigation·T G Redgrave
Mar 16, 1971·Biochimica Et Biophysica Acta·L Swell, M D Law
Oct 1, 1968·The Journal of Cell Biology·Y SteinO Stein
Jun 10, 1969·Biochimica Et Biophysica Acta·S H Uarfordt, D S Goodman
Nov 1, 1967·Archives of Biochemistry and Biophysics·H G Windmueller, A E Spaeth
Dec 1, 1952·Proceedings of the Society for Experimental Biology and Medicine·M D SIPERSTEINW G DAUBEN
Oct 1, 1962·The Journal of Clinical Investigation·D S GOODMAN
Nov 1, 1962·Clinica Chimica Acta; International Journal of Clinical Chemistry·A L BABSONG E PHILLIPS

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Citations

Jun 1, 1977·Acta Physiologica Scandinavica·J ViikariT Nikkari
Jan 1, 1981·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·S Stender, D B Zilversmit
Sep 28, 1977·Biochimica Et Biophysica Acta·A D Cooper
Jan 1, 1978·Progress in Lipid Research·F P Bell

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