PMID: 1202197Oct 1, 1975Paper

Transfer of fatty acids across the rabbit placenta

The Journal of Physiology
M C ElphickD Hull

Abstract

1. Transfer of fatty acids across the placenta was studied in anaesthetized rabbits at 28-days gestation by measuring umbilical venous-arterial differences, by injection of labelled palmitate into the mother and observing its appearance in the foetus, by injection of labelled palmitate into the foetus and measuring its appearance in the mother and the foetal clearance rate. 2. The release of fatty acids and glycerol by foetal adipose tissues was investigated in vitro by measuring the effect of addition of noradrenaline to the incubation medium and in vivo by measuring the effect of noradrenaline infusion into the foetus on circulating glycerol and free fatty acid concentrations. 3. In anaesthetized rabbits at 28-days gestation the maternal circulating free fatty acid concentrations were high and there was a positive umbilical venous-arterial difference. High maternal free fatty acid concentrations were associated with high umbilical venous-arterial differences. 4. Label was present in the foetus in 2 min and reached a peak in 3 min after injection of labelled palmitate into the mother. Label appeared in the maternal circulation in 1 min after injection into the foetus. The half-life of labelled palmitate was of the order of 30-...Continue Reading

Citations

Jan 1, 1994·Molecular Aspects of Medicine·G Desoye, E Shafrir
Jul 1, 1976·British Journal of Obstetrics and Gynaecology·M C ElphickR R Sanders
Jul 1, 1987·Placenta·R BrandesV Barash
Sep 24, 2008·Journal of Evolutionary Biology·M G Elliot, B J Crespi
Sep 1, 1985·British Journal of Obstetrics and Gynaecology·W HendrickseD Hull
Dec 2, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jin-Ran ChenKartik Shankar
Jan 1, 1995·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·S J IversonJ Sampugna
Jun 1, 1991·The American Journal of Physiology·M GilbertF C Battaglia
Jan 16, 1990·Biochimica Et Biophysica Acta·L W GonzalesJ Gonzales
Sep 28, 1977·Biochimica Et Biophysica Acta·D W SeccombeF Possmayer
Apr 22, 2021·Endocrinology·Niall Graham, Guo N Huang
Dec 1, 1996·Seminars in Perinatology·R J Ascuitto, N T Ross-Ascuitto

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