PMID: 7537323Jan 1, 1995Paper

Transfer of graded potentials at the photoreceptor-interneuron synapse

The Journal of General Physiology
M JuusolaM Weckström

Abstract

To characterize the transfer of graded potentials and the properties of the associated noise in the photoreceptor-interneuron synapse of the blowfly (Calliphora vicina) compound eye, we recorded voltage responses of photoreceptors (R1-6) and large monopolar cells (LMC) evoked by: (a) steps of light presented in the dark; (b) contrast steps; and (c) pseudorandomly modulated contrast stimuli at backgrounds covering 6 log intensity units. Additionally, we made recordings from photoreceptor axon terminals. Increased light adaptation gradually changed the synaptic signal transfer from low-pass to band-pass filtering. This was accompanied by decreased synaptic delay and increased contrast gain, but the overall synaptic gain and the intrinsic noise (i.e., transmission noise) were reduced. Based on these results, we describe a descriptive synaptic model, in which the kinetics of the tonic transmitter (histamine) release from the photoreceptor axon terminals change with mean photoreceptor depolarization. During signal transmission, tonic transmitter release is augmented by voltage-dependent contrast-enhancing mechanisms in the photoreceptor axons that produce fast transients from the rising phases of the photoreceptor responses and add ...Continue Reading

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Citations

May 20, 1999·The Journal of Comparative Neurology·M Shimohigashi, Y Tominaga
Jan 9, 2008·Biological cybernetics·Jens Peter LindemannMartin Egelhaaf
Apr 26, 2006·The Journal of General Physiology·Lei ZhengMikko Juusola
Nov 25, 2011·Journal of Neurophysiology·Peter W Jones, Fabrizio Gabbiani
Nov 7, 2009·PLoS Computational Biology·Russell S A Brinkworth, David C O'Carroll
Nov 19, 2013·PLoS Computational Biology·Damon A ClarkRava Azeredo da Silveira
Dec 20, 2007·PloS One·Jan GreweAnne-Kathrin Warzecha
May 15, 2008·PloS One·Olivier Faivre, Mikko Juusola
Nov 13, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paloma T Gonzalez-BellidoMikko Juusola
Oct 1, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ahmad N Abou TayounPatrick J Dolph
Apr 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter W Jones, Fabrizio Gabbiani
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Oct 26, 2016·Current Biology : CB·Damon A Clark, Jonathan B Demb
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Dec 28, 2017·PLoS Computational Biology·Jinglin LiMartin Egelhaaf
Dec 21, 2019·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Roman V Frolov, Irina I Ignatova
Sep 1, 2020·PLoS Genetics·Maureen M SampsonDavid E Krantz
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Nov 8, 2016·Frontiers in Computational Neuroscience·Jinglin LiMartin Egelhaaf
Jul 30, 2021·Current Biology : CB·Omer ManoDamon A Clark

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