Transfer of insulin lispro across the human placenta

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Gershon HolcbergZvi Ben Zvi

Abstract

Our in vitro perfusion study confirms the result of the Boskovic et al., that insulin lispo is not crossing the human placental membranes at low concentrations. In our study maternal steady state concentration reached 48 +/- microU in the maternal artery and 28 +/- 1 microU in the maternal vein, while in the fetal site insulin lispo was not detected. However, the concentration of insulin lispo in placental tissue was 1836 +/- 220 microU.

References

Sep 10, 1999·Diabetes Care·L JovanovicE J Bastyr
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Apr 30, 2003·Diabetes Care·Rada BoskovicGideon Koren

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Citations

Nov 13, 2010·Current Diabetes Reports·Celeste P Durnwald, Mark B Landon
Dec 28, 2010·Journal de gynécologie, obstétrique et biologie de la reproduction·S Jacqueminet, M-F Jannot-Lamotte
Oct 10, 2006·Diabetes, Obesity & Metabolism·Ivana Zib, Philip Raskin
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Dec 30, 2021·Diabetes Care·UNKNOWN American Diabetes Association Professional Practice CommitteeMikhail Kosiborod

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